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PubMed · 16390875

From sequences to a functional unit.

Ashwin Sivakumar·Christopher Wilton·Liisa Holm
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Abstract

Functional insights at the gene product level would help the drug discovery industry to effectively tap targets for therapeutics and biomedical applications. A complete functional unit can be multidomain, and it is the co-occurrence and interaction of these multiple domains that determine the function and functional diversity of their gene products. With at least 10% of genes from complete genomes existing in fused form, identifying gene fusion events helps us categorize the protein universe into distinct functional units with only sequence information.

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AnimalsBacterial ProteinsDatabases, Nucleic AcidDatabases, ProteinEscherichia coliEvolution, MolecularGene FusionHumansProtein Structure, QuaternaryProteinsSequence AlignmentSequence Homology, Amino AcidSequence Homology, Nucleic AcidJournal ArticleResearch Support, Non-U.S. Gov't

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Ashwin Sivakumar, Christopher Wilton, Liisa Holm. 2006-01-03. From sequences to a functional unit.. https://doi.org/10.1152/physiolgenomics.00166.2005

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