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PubMed · 16185903

Improved time efficiency and accuracy in diffusion tensor microimaging with multiple-echo acquisition.

Vikas Gulani·Thomas Weber·Thomas Neuberger·Andrew G Webb
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Abstract

In high-field NMR microscopy rapid single-shot imaging methods, for example, echo planar imaging, cannot be used for determination of the apparent diffusion tensor (ADT) due to large magnetic susceptibility effects. We propose a pulse sequence in which a diffusion-weighted spin-echo is followed by multiple gradient-echoes with additional diffusion weighting. These additional echoes can be used to calculate the ADT and T*2 maps. We show here that this results in modest but consistent improvements in the accuracy of ADT determination within a given total data acquisition time. The method is tested on excised, chemically fixed rat spinal cords.

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AnimalsAnisotropyDiffusion Magnetic Resonance ImagingFemaleRatsSpinal CordJournal ArticleResearch Support, Non-U.S. Gov't

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Vikas Gulani, Thomas Weber, Thomas Neuberger, Andrew G Webb. 2005-09-23. Improved time efficiency and accuracy in diffusion tensor microimaging with multiple-echo acquisition.. https://doi.org/10.1016/j.jmr.2005.08.007

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