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PubMed · 16181672

Polyurethane biocidal polymeric surface modifiers.

Umit Makal·Lynn Wood·Dennis E Ohman·Kenneth J Wynne
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Abstract

Polyurethanes (PUs) with soft blocks containing semifluorinated (-CH2OCH2CF3) and 5,5-dimethylhydantoin pendant groups were prepared and employed (2 wt%) as biocidal polymeric surface modifiers (PSMs) for a conventional PU coating comprised of an isophorone diisocyanate/1,4-butanediol-derived hard block (50%) and poly(tetramethylene oxide) soft block. Surface enrichment of the PSM was verified by dynamic contact angle measurements. The PSM modified PU was activated by converting near-surface amide groups to chloramide with 3wt% hypochlorite. The conversion of near-surface amide to chloramide is reflected in somewhat increased hydrophobic character for the antimicrobial chloramide functionalized surfaces. Biocidal activity against both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa, and Escherichia coli) bacteria was demonstrated by using a modified version of American Association of Textile Chemists and Colorists (AATCC-100) test. By changing the PSM concentration it was found that only 1.6 wt% PSM (0.66 wt% biocide, 5,5-dimethylhydantoin) in a conventional PU affected complete kill of P. aeruginosa in 15 min by using this biocidal testing protocol.

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Anti-Infective AgentsEscherichia coliFluorineHydantoinsMicrobial Sensitivity TestsNanotechnologyPolyurethanesPseudomonas aeruginosaStaphylococcus aureusSurface PropertiesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.

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Umit Makal, Lynn Wood, Dennis E Ohman, Kenneth J Wynne. 2005-09-21. Polyurethane biocidal polymeric surface modifiers.. https://doi.org/10.1016/j.biomaterials.2005.08.038

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