PubMed · 16168089
Our bright young biologists should start thinking now about the ethical issues of what we can do and will be able to do in the future.
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Gregory A Petsko. 2005-08-30. Trinity.. https://doi.org/10.1186/gb-2005-6-9-118
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Addressing health inequity is now recognized as a clinical competency in medical education. We examined the career and writings of Robert Wilson Jr. (1867-1946), longtime dean of the Medical College of the State of South Carolina during the Jim Crow Era, using primary and secondary sources within the context of systemic and structural racism, particularly in South Carolina. Wilson used public health data to refute the "Black Extinction Hypothesis" rooted in social Darwinism. He challenged assumptions of inherent Black susceptibility to tuberculosis, linking disease instead to social determinants of health. He also identified disproportionate mortality from kidney and cardiovascular disease among Black populations, anticipating modern health disparities research. Wilson further acknowledged systemic injustice and implicated structural conditions, including housing, in shaping outcomes. In an era of continuing health inequity and racial health disparities, Wilson applied empirical evidence to reject biological determinism, identify outcomes disparities, and advocate for racial justice.
A personal narrative of my time in the Hunt laboratory and beyond is provided. The impact of the Hunt laboratory on the analysis of peptides and proteins by tandem mass spectrometry is described in the context of the time.
We performed a systematic search for literature dealing with tissue microarray technology. During the last two decades, these procedures have developed into a powerful tool for the high-throughput analysis of tissue specimens. This technology offers the following advantages: amplification of a scarce resource, experimental uniformity (tissue of multiple patients are treated in an identical manner), decreased assay volume, preservation of original blocks, amenability to a wide range of techniques and evaluation of tissue from multiple patients on the same slide. Depending on the shape of the tissue sample and the method used to obtain it, multitissue array techniques may be classified into two different groups: rod-shaped tissue techniques and core tissue techniques. These techniques have been used for quality control, diagnosis, and teaching and screening purposes. Some technical aspects should be considered when deciding which technique should be used: the number, size and origin of tissue samples; the quality of paraffin wax, the distance between samples and the depth in the receptor block; antigenicity preservation and block sectioning. This review shows different techniques, the use of which is dependent on the requirements of the arrays and the technical possibilities.