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PubMed · 16135854

Interfering with longevity.

Siu Sylvia Lee
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Abstract

Several recent studies have highlighted how RNA interference has advanced aging-related research in Caenorhabditis elegans. Two new genome-wide RNAi-based screens together identified more than 100 new candidate longevity genes. RNAi has also greatly facilitated the functional validation of several large-scale gene expression profiling studies. Furthermore, RNAi is flexible and can be administered at different times throughout life; this feature has been exploited to analyze the temporal requirement of genes in life-span determination.

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AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDown-RegulationLongevityRNARNA InterferenceTime FactorsJournal ArticleReview

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BibTeXRIS

Siu Sylvia Lee. 2005-08-31. Interfering with longevity.. https://doi.org/10.1126/sageke.2005.35.pe26

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