Self-administering cannabinoids.

Lindsey L Glickfeld; Massimo Scanziani

doi:10.1016/j.tins.2005.05.001

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PubMed · 15979498

Self-administering cannabinoids.

Lindsey L Glickfeld·Massimo Scanziani

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Abstract

Endocannabinoids, which are typically released by principal cells in response to prolonged depolarization, act as retrograde messengers to inhibit synaptic transmission. A recent study shows that in a specific subtype of cortical interneuron, endocannabinoids released under similar circumstances can also act cell-autonomously. Here, endocannabinoids endow these neurons with a memory of their own activity in the form of a long-term change in excitability.

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Animals Autocrine Communication Cannabinoid Receptor Modulators Cannabinoids Neurons Self Administration Synaptic Transmission Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.Review

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Lindsey L Glickfeld, Massimo Scanziani. 2005. Self-administering cannabinoids.. https://doi.org/10.1016/j.tins.2005.05.001

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