Search PubMed⌕ Search

PubMed · 1592544

Toothpastes.

Abstract

It is well known that plaque is the main cause of caries and parodontopathies, which puts the role of toothpastes as an important means of prevention of odontopathies to the foreground. Toothpastes can be more or less oriented towards having a particular effect, such as cleaning, anticaries effect, antimicrobial effect or inhibition of the formation of tartar. Toothpastes contain substances which promote dental health, such as abrasives (silicium dioxide, brushite, calcite, calcite and aragonite, gibbsite etc.), active components (fluorides, triclosan, metal ions, sanguinarine and surface-active substances), substances which motivate the use of toothpaste (sweetening agents, aromatic oil, colours) and components which are necessary for technical reasons, such as moisturizing agents, binders and opacifiers.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

P Städtler, H Höller. 1992. Toothpastes.. https://pubmed.ncbi.nlm.nih.gov/1592544/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding.

Regulated shedding of cell surface proteins is a mechanism for rapid activation of autocrine and paracrine signaling. Here we report that chelerythrine, a protein kinase C (PKC) inhibitor that possesses a variety of biological functions, is a potent inducer of heparin-binding epidermal growth factor-like growth factor (HB-EGF) shedding from the cell surface. Chelerythrine induced a time- and dose-dependent shedding of an HB-EGF-alkaline phosphatase (HB-EGF-AP) fusion protein expressed in MC2 rat prostate epithelial cells. The soluble form of HB-EGF-AP bound to heparin and exhibited potent biological activity as measured by DNA synthesis assay. Chelerythrine-induced HB-EGF shedding was metalloproteinase-(MMP-) mediated because specific MMP antagonists inhibited shedding by > or =60%. Chelerythrine stimulated production of reactive oxygen species, and antioxidants prevented chelerythrine-induced HB-EGF shedding, suggesting that the production of intracellular peroxides is necessary for this event. Consistent with this possibility, antioxidant- and MMP-inhibitable shedding was also demonstrated when hydrogen peroxide was used as an inducer. Although JNK/SAPK and p38 MAPK pathways were activated by chelerythine, these signaling mechanisms were not required to mediate the shedding event. However, JNK signaling was involved in chelerythrine-stimulated apoptosis. Our results suggest that HB-EGF shedding induced by chelerythrine is mediated predominantly via the production of reactive oxygen species.

Alkaloids↗