PubMed · 15821459
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Dolores J Lamb, Lixin Zhang, Ralph Buttyan. 2005. A problem with a chaperone.. https://doi.org/10.1097/01.ju.0000159654.08981.25
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The PRDM1 gene, a master regulator of plasma cells (PC), can generate two transcription factor isoforms: PRDI-BF1alpha and PRDI-BF1beta. The present study shows that purified human normal PC have a significantly lower levels of PRDI-BF1beta expression than that in tumoral PC isolated from multiple myeloma (MM) (0.06+/-0.01 and 0.25+/-0.05, respectively; p<0.001). The role of this finding in MM is discussed.
TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.
MicroRNAs (miRNAs) are short endogenous noncoding small RNA molecules with 21 to 25 nucleotides (nt) in length, which negatively regulate gene expression either by degrading specific mRNA or impeding translation at the transcriptional and post-transcriptional level. Recent advances suggest that miRNAs play prominent roles in development, genome organization, viral and transposon defense, and human disease, including neurodegenerative and metabolic diseases. Surprisingly, miRNAs are now linked with a variety of cancers, in which a reduced expression or overexpression may lead to oncogene or tumor suppressor gene-like actions. Here we will overview the miRNA pathway and its regulation with emphasis on the links with human cancer. Finally potential applications of miRNA in tumor diagnosis and therapy will be discussed.