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PubMed · 15820558

Occludin: structure, function and regulation.

Gemma J Feldman·James M Mullin·Michael P Ryan
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Abstract

Epithelial and/or endothelial barriers play a critical role in animal, including human, life forms. The tight junction (TJ) is an essential component of these barriers. Occludin is a major component of the TJ. The structure of occludin, including its gene splice variants and protein essential components have been elucidated. Phosphorylation/dephosphorylation plays a major role in regulation of occludin and TJ. Disruption of occludin regulation is an important aspect of a number of diseases. Strategies to prevent and/or reverse occludin downregulation may be an important therapeutic target.

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AnimalsHumansMembrane ProteinsOccludinStructure-Activity RelationshipJournal ArticleReview

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Gemma J Feldman, James M Mullin, Michael P Ryan. 2005-04-25. Occludin: structure, function and regulation.. https://doi.org/10.1016/j.addr.2005.01.009

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