Predicting enzyme function from protein sequence.

Jeremy Minshull; Jon E Ness; Claes Gustafsson; Sridhar Govindarajan

doi:10.1016/j.cbpa.2005.02.003

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Predicting enzyme function from protein sequence.

Jeremy Minshull·Jon E Ness·Claes Gustafsson·Sridhar Govindarajan

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Abstract

There are two main reasons to try to predict an enzyme's function from its sequence. The first is to identify the components and thus the functional capabilities of an organism, the second is to create enzymes with specific properties. Genomics, expression analysis, proteomics and metabonomics are largely directed towards understanding how information flows from DNA sequence to protein functions within an organism. This review focuses on information flow in the opposite direction: the applicability of what is being learned from natural enzymes to improve methods for catalyst design.

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Animals Enzymes Humans Protein Engineering Sequence Analysis, Protein Structural Homology, Protein Journal Article Review

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Jeremy Minshull, Jon E Ness, Claes Gustafsson, Sridhar Govindarajan. 2005. Predicting enzyme function from protein sequence.. https://doi.org/10.1016/j.cbpa.2005.02.003

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