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PubMed · 15575891

Another cause for the same old problem.

John D Pirsch·Bryan N Becker
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AnemiaCardiovascular DiseasesComorbidityGlomerular Filtration RateHumansKidney Failure, ChronicKidney TransplantationCommentEditorialResearch Support, U.S. Gov't, P.H.S.Review

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John D Pirsch, Bryan N Becker. 2004. Another cause for the same old problem.. https://doi.org/10.1111/j.1600-6143.2004.00645.x

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Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ.

Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival rate and several pathological features in C57BL/6JTnf(-/-) and C57BL/6JTnf(+/+) mice after infection with Plasmodium chabaudi adami 408XZ. Compared to the C57BL/6JTnf(+/+) mice, C57BL/6JTnf(-/-) mice showed increased parasitemia and decreased survival rate, whereas blood glucose, blood lactate and body weight were not significantly different. However, C57BL/6JTnf(-/-) mice suffered significantly more from severe anemia and hypothermia than C57BL/6JTnf(+/+) mice. These results suggest that Tnf is an important mediator of parasite control, but not of anemia development. We hypothesize that the high mortality observed in the Tnf knock-out mice is due to increased anemia and pathology as a direct result of increased levels of parasitemia.

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