'Cap-tabolism'.

Nicolas Cougot; Erwin van Dijk; Sylvie Babajko; Bertrand Séraphin

doi:10.1016/j.tibs.2004.06.008

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PubMed · 15362228

'Cap-tabolism'.

Nicolas Cougot·Erwin van Dijk·Sylvie Babajko·Bertrand Séraphin

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Abstract

distinctive feature of eukaryotic mRNA and small nuclear RNA (snRNA) that are transcribed by RNA polymerase II (Pol II) is the presence of a cap structure at their 5' end. This essential modification serves as an inviting 'landing pad' for factors that are involved in various cellular processes such as pre-mRNA splicing, nucleocytoplasmic RNA export and localization, and translation initiation. Because of the important functions mediated by the mRNA cap, this structure needs to be modified and/or degraded in a tightly controlled manner. Several cellular and viral systems implicated in cap metabolism have been uncovered recently; their analyses provide interesting new information on cell structure and function.

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Animals Cell Nucleus Humans RNA Cap-Binding Proteins RNA Caps RNA Processing, Post-Transcriptional RNA, Small Nuclear Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't Review

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Nicolas Cougot, Erwin van Dijk, Sylvie Babajko, Bertrand Séraphin. 2004. 'Cap-tabolism'.. https://doi.org/10.1016/j.tibs.2004.06.008

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