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PubMed · 15181995

Second-harmonic optical coherence tomography.

Yi Jiang·Ivan Tomov·Yimin Wang·Zhongping Chen
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Abstract

Second-harmonic optical coherence tomography, which uses coherence gating of second-order nonlinear optical responses of biological tissues for imaging, is described and demonstrated. Femtosecond laser pulses were used to excite second-harmonic waves from collagen harvested from rat tail tendon and a reference non-linear crystal. Second-harmonic interference fringe signals were detected and used for image construction. Because of the strong dependence of second-harmonic generation on molecular and tissue structures, this technique imparts contrast and resolution enhancement to conventional optical coherence tomography.

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AnimalsBirefringenceCollagenImage EnhancementImage Interpretation, Computer-AssistedRatsTailTomography, Optical CoherenceComparative StudyEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Validation Study

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Yi Jiang, Ivan Tomov, Yimin Wang, Zhongping Chen. 2004-05-15. Second-harmonic optical coherence tomography.. https://doi.org/10.1364/ol.29.001090

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