Organizing pains.

Emer M Garry; Susan M Fleetwood-Walker

doi:10.1016/j.tins.2004.03.014

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PubMed · 15165730

Organizing pains.

Emer M Garry·Susan M Fleetwood-Walker

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Abstract

Chronic pain is sustained by central neuronal sensitization, with many similar characteristics irrespective of the type of injury incurred. Nevertheless, pain arising from nerve injury (neuropathic pain) is resistant to centrally acting analgesics, whereas inflammatory pain responds well. New research indicates that the role of spinal NMDA receptors in chronic pain depends on adaptor proteins of the membrane-associated guanylate kinase (MAGUK) family and raises the possibility that complexes of different composition might contribute differentially to different pain states.

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Animals Guanylate Kinases Humans Nucleoside-Phosphate Kinase Pain Receptors, N-Methyl-D-Aspartate Spinal Cord Journal Article Research Support, Non-U.S. Gov't

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Emer M Garry, Susan M Fleetwood-Walker. 2004. Organizing pains.. https://doi.org/10.1016/j.tins.2004.03.014

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