Polyphenolics and fat absorption.

S Pal; M Naissides; J Mamo

doi:10.1038/sj.ijo.0802577

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PubMed · 14970839

Polyphenolics and fat absorption.

S Pal·M Naissides·J Mamo

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Abstract

OBJECTIVES: To elucidate whether the acute consumption of red wine polyphenolic compounds regulates lipid and lipoprotein metabolism in dyslipidemic postmenopausal women. DESIGN: Eight dyslipidemic postmenopausal women each consumed a mixed meal accompanied by either water, dealcoholized red wine or alcoholic red wine on three separate visits, in a random order, 2 weeks apart. One fasting and six hourly postmeal blood samples were taken and analyzed for plasma apolipoprotein B48 (apoB48; specific marker of chylomicrons (CM) and their remnants (CMR)); total-, LDL- and HDL-cholesterol; triglycerides (TAG); insulin and glucose at each time point. RESULTS: There was a decrease in postprandial apoB48 levels after alcoholic and nonalcoholic red wine consumption compared to water. CONCLUSION: Red wine attenuates postprandial CM and CMR levels in plasma, possibly by delaying the absorption of dietary fat, as suggested by a decrease in plasma apoB48 levels. The reduction of postprandial lipoproteins in circulation after red wine consumption may partly explain the low cardiovascular mortality rates among the French.

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Apolipoprotein B-48 Apolipoproteins B Female Flavonoids Humans Hyperlipidemias Intestinal Absorption Lipids Phenols Polyphenols Postmenopause Postprandial Period Wine Clinical Trial Journal Article Randomized Controlled Trial

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S Pal, M Naissides, J Mamo. 2004. Polyphenolics and fat absorption.. https://doi.org/10.1038/sj.ijo.0802577

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