Complement receptor 2 and autoimmunity.

V Michael Holers; Susan A Boackle

doi:10.1159/000075686

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PubMed · 14719374

Complement receptor 2 and autoimmunity.

V Michael Holers·Susan A Boackle

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Abstract

Complement receptor 2 (CR2/CD21) plays a major role in the immune response by linking innate and adaptive immunity to foreign pathogens and proteins. In addition, several lines of evidence strongly support a role for CR2 in the maintenance of tolerance to self-antigens. Both the absence of CR2 expression (along with the alternatively spliced gene product CR1) and the presence of a dysfunctional CR2 protein are tightly associated with the development of autoreactivity to nuclear antigens. Altered levels of expression of CR2 in patients with systemic lupus erythematosus support a clinically relevant role for this phenotype. Several possible mechanisms could underlie the loss of self-tolerance related to CR2, but the effect is most likely related to the failure of one or more specific checkpoints that limit autoreactivity during B cell development and immune reactions.

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Animals Autoimmunity Herpesvirus 4, Human Humans Lupus Erythematosus, Systemic Models, Animal Receptors, Complement 3d Receptors, Virus Journal Article Review

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V Michael Holers, Susan A Boackle. 2004. Complement receptor 2 and autoimmunity.. https://doi.org/10.1159/000075686

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