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Genetics and functional genomics of type 2 diabetes mellitus.

Ayo Toye·Dominique Gauguier
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Abstract

Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1alpha. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus.

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AnimalsDiabetes Mellitus, Type 2GenomicsHumansMuscle, SkeletalOxidative PhosphorylationTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Ayo Toye, Dominique Gauguier. 2003-11-24. Genetics and functional genomics of type 2 diabetes mellitus.. https://doi.org/10.1186/gb-2003-4-12-241

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