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PubMed · 14651742

Leukaemic stem cells.

A Blair·D H Pamphilon
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Abstract

All haemopoietic cell lineages arise from multipotential self-renewing stem cells that give rise to committed progenitor cells. These progenitor cells subsequently differentiate into more lineage-committed cells with a restricted range of plasticity. A hierarchical order is considered to exist, where lineage commitment and differentiation are thought to be irreversible. As cells differentiate, they gradually lose the ability to self-renew. The most primitive haemopoietic progenitor cells have the ability to reconstitute long-term haemopoiesis in myeloablated recipients. However, as cells differentiate, there is an orchestrated silencing of some genes and activation of others, resulting in lineage commitment and generally a reduction in proliferative ability. Here, we discuss potential differences between normal and leukaemic stem cells, some of which may have therapeutic implications.

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AnimalsAntigens, CD34Antineoplastic AgentsCell Line, TumorCell Transformation, NeoplasticDogsDrug DesignHematopoietic Stem CellsHumansLeukemiaMiceMice, Inbred NODMice, SCIDNeoplastic Stem CellsOncogene Proteins, FusionSheepTranslocation, GeneticTumor Stem Cell AssayXenograft Model Antitumor AssaysJournal ArticleReview

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A Blair, D H Pamphilon. 2003. Leukaemic stem cells.. https://doi.org/10.1111/j.1365-3148.2003.00464.x

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