Negative selection and autoimmunity.

Pamela S Ohashi

doi:10.1016/j.coi.2003.09.013

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Negative selection and autoimmunity.

Pamela S Ohashi

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Abstract

The impaired elimination of self-reactive T cells is one factor that contributes to autoimmunity. Although the mechanism of thymic negative selection has been studied for decades, recent data demonstrate that the mechanisms underlying this fundamental process remain extremely controversial. Nonetheless, new models such as the Aire-deficient mice have demonstrated the importance of thymic negative selection in autoimmune disease progression in mice and humans.

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Animals Apoptosis Autoimmunity Clonal Deletion Humans Receptors, Tumor Necrosis Factor Transcription Factors Tumor Necrosis Factor-alpha AIRE Protein Journal Article Review

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Pamela S Ohashi. 2003. Negative selection and autoimmunity.. https://doi.org/10.1016/j.coi.2003.09.013

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