PubMed · 14277464
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Y YANAGAVA. 1964. [SOME BASIC PROBLEMS IN DIHYDROSTREPTOMYCIN DEAFNESS].. https://doi.org/10.3950/jibiinkoka.67.12_1694
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Surface and bulk modification techniques of polydimethylsiloxane (PDMS) polymers were used to develop a new intracochlear electrode that can closely hug the inner wall of scala tympani. Laser-induced surface grafting of poly (2-hydroxyethyl methacrylate) (PHEMA) and sequential method for preparation of interpenetrating polymer networks (IPNs) of PDMS/PHEMA were, respectively, used for surface and bulk modifications. The hydrogel content and water-uptake capability of the modified samples were optimized by Taguchi method for experimental design. The modified PDMS samples were examined by performing attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, water contact-angle measurement, and peel strength tests. The performances of actual-sized fabricated electrodes were assessed inside a transparent model of scala tympani, which was filled with saline. After a swelling process, the hydrophilic branch begins to elongate and detach from hydrophobic branch and pushes it toward the inner wall.
We previously described a model for loudness perception for people with cochlear hearing loss. However, that model is incompatible with our most recent and most satisfactory model of loudness for normal hearing. Here, we describe a loudness model that is applicable to both normal and impaired hearing. In contrast to our earlier model for impaired hearing, the new model correctly predicts: (1) that a sound at absolute threshold has a small but finite loudness; (2) that, for levels very close to the absolute threshold, the rate of growth of loudness is similar for normal ears and ears with cochlear hearing loss; (3) the relation between monaural and binaural threshold and loudness; (4) recent measures of equal-loudness contours. Like the earlier model, the new model can account for the loudness recruitment and reduced loudness summation that are typically associated with cochlear hearing loss.
AIM OF THE STUDY: To compare high resolution MRI examinations of inner ear structures at 1.5 T and at 3 T. METHOD: Temporal bones were measured bilaterally in 3 healthy volunteers in a 1.5 T and in a 3 T MR-scanner using the respective one channel head coil (quadrature detection) of the manufacturer. The same steady-state gradient echo sequence (3D-CISS) was employed at a voxel size of 0.4 x 0.4 x 0.4 mm(3). The signal-to-noise ratio (SNR) was determined quantitatively. RESULTS: An SNR of 8 could be achieved for the measurements at 3 T in 7:37 min. The SNR at 3 T was, on average, a factor of 1.34 higher than that at 1.5 T despite the fact that the excitation angle had to be drastically reduced (alpha = 42 degrees instead of alpha = 70 degrees at 1.5 T) due to the limit of the specific absorption rate (SAR). DISCUSSION: The MR representation of the inner ear is clearly improved at 3 T. To obtain the same SNR at 1.5 T approximately the double measuring time would be required, connected with reduced patient comfort and an increased risk for a displacement of the head during the high resolution measurement.