Nuclear pore structure and function.

M Stewart

doi:10.1016/1043-4682(92)90028-t

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Nuclear pore structure and function.

M Stewart

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Abstract

Nuclear pores are huge macromolecular assemblies, approximately 120 nm in diameter, that perforate the nuclear membrane and mediate nucleocytoplasmic transport. Nuclear pores are constructed from a cylindrical spoke-plug complex sandwiched between nucleoplasmic and cytoplasmic rings. The spoke-plug complex has pronounced 8-fold rotational symmetry, which is also present in the rings. Nucleocytoplasmic transport is an energy-requiring process that takes place through the centre of the pores and can accommodate particles up to about 25 nm diameter. Translocation is preceded by a separate binding step which does not require energy. Several nuclear pore proteins have been isolated and characterized. Many of these proteins contain O-linked N-acetyl glucosamine residues and may have similar modular domain structures.

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Animals Biological Transport Cell Nucleus Cytoplasm Membrane Glycoproteins Microscopy, Electron Molecular Weight Nuclear Envelope Nuclear Proteins Journal Article Review

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M Stewart. 1992. Nuclear pore structure and function.. https://doi.org/10.1016/1043-4682(92)90028-t

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