Thymic selection.

D Pardoll; A Carrera

doi:10.1016/0952-7915(92)90006-z

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Thymic selection.

D Pardoll·A Carrera

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Abstract

The ability of T cells to recognize foreign antigens, distinguish them from self antigens, and regulate immune responses depends largely on which of the vast array of different T-cell receptors they display on their surface, the so called T-cell repertoire. Two selection processes, positive and negative selection, operate on developing T cells and allow only a subset of all possible T cells to differentiate. New developments in transgenic mouse technology and the study of T-cell signalling are unravelling these fascinating processes.

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Animals CD4-Positive T-Lymphocytes Mice Mice, Transgenic Receptors, Antigen, T-Cell T-Lymphocytes T-Lymphocytes, Regulatory Thymus Gland Journal Article Review

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D Pardoll, A Carrera. 1992. Thymic selection.. https://doi.org/10.1016/0952-7915(92)90006-z

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