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PubMed · 12857982

Complement: structure, functions, evolution, and viral molecular mimicry.

Dimitrios Mastellos·Dimitrios Morikis·Stuart N Isaacs·M Claire Holland·Cristoph W Strey·John D Lambris
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Abstract

The complement (C') system has long been recognized as an important mediator of innate immune defense and inflammation. In recent years there is increasing evidence suggesting that complement components may also participate in non-inflammatory and developmental processes. Here we review our current work on the structural-functional aspects of C3-ligand interactions and the rational design of small-sized complement inhibitors. We present a novel, proteomics-based, approach to studying protein-protein interactions within the C' system and discuss our progress in the study of viral immune evasion strategies. Furthermore we discuss the involvement of complement proteins in organ regeneration and hematopoietic development.

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AnimalsComplement C3Complement Inactivator ProteinsComplement System ProteinsEvolution, MolecularHumansLigandsMolecular MimicryStructure-Activity RelationshipVirus DiseasesJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Dimitrios Mastellos, Dimitrios Morikis, Stuart N Isaacs, M Claire Holland, Cristoph W Strey, John D Lambris. 2003. Complement: structure, functions, evolution, and viral molecular mimicry.. https://doi.org/10.1385/ir%3A27%3A2-3%3A367

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