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PubMed · 12770700

Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.

Martine Poncelet·Jeanne Maruani·Roselyne Calassi·Philippe Soubrié
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Abstract

Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1-/- vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models.

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Alcohol DrinkingAnimalsEatingFood PreferencesMiceMice, Inbred C57BLMice, KnockoutNeuropeptide YPiperidinesPyrazolesReceptors, CannabinoidReceptors, DrugRimonabantSucroseJournal Article

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Martine Poncelet, Jeanne Maruani, Roselyne Calassi, Philippe Soubrié. 2003-06-12. Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.. https://doi.org/10.1016/s0304-3940(03)00397-5

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