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Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs.

Yesim Ozarda Ilcol·Zeki Yilmaz·Ismail H Ulus
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Abstract

We designed this study to determine whether serum free and phospholipid-bound choline concentrations change after surgery or methylprednisolone treatment in dogs and rats. In dogs, serum free and phospholipid-bound choline concentrations were decreased by 29% and 17% immediately after abdominal-pelvic surgery under xylasine+ketamine anesthesia, respectively, and both remained low for 24 h. Serum cortisol was elevated after surgery. The elevation in serum cortisol was inversely correlated with the decreases in free (r=-0.737; P<0.001) and phospholipid-bound (r=-0.771; P<0.001) choline concentrations. After methyprednisolone administration (5-20 mg/kg) free and phospholipid-bound choline concentrations decreased in a dose- and time-dependent manner. In rats, either surgery or methylprednisolone failed to alter serum free choline concentrations while phospholipid-bound choline decreased after surgery. These data show that the decrease in serum choline after surgery results from the increase in circulating glucocorticoids.

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AnimalsCholineDogsFemaleHysterectomyMethylprednisoloneOvariectomyPhospholipidsRatsRats, WistarComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Yesim Ozarda Ilcol, Zeki Yilmaz, Ismail H Ulus. 2003-03-27. Serum free and phospholipid-bound choline decrease after surgery and methylprednisolone administration in dogs.. https://doi.org/10.1016/s0304-3940(03)00035-1

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