Pulmonary surfactant: phase behavior and function.

Barbora Piknova; Vincent Schram; Stephen B Hall

doi:10.1016/s0959-440x(02)00352-4

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Pulmonary surfactant: phase behavior and function.

Barbora Piknova·Vincent Schram·Stephen B Hall

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Abstract

Pulmonary surfactant functions by first flowing rapidly into the alveolar air/water interface, but then resisting collapse from the surface when the adsorbed interfacial film is compressed during exhalation. Widely accepted models emphasize the importance of phase behavior in both processes. Recent studies show, however, that fluidity is a relatively minor determinant of adsorption and that solid films, which resist collapse, can form by kinetic processes unrelated to equilibrium phase behavior.

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1,2-Dipalmitoylphosphatidylcholine Adsorption Air Lipids Proteolipids Pulmonary Alveoli Pulmonary Surfactants Surface Tension Water Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Barbora Piknova, Vincent Schram, Stephen B Hall. 2002. Pulmonary surfactant: phase behavior and function.. https://doi.org/10.1016/s0959-440x(02)00352-4

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