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PubMed · 11988749

Taking a bite: proteasomal protein processing.

Michael Rape·Stefan Jentsch
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Abstract

The proteasome is a hollow cylindrical protease that contains active sites concealed within its central cavity. Proteasomes usually completely degrade substrates into small peptides, but in a few cases, degradation can yield biologically active protein fragments. Examples of this are the transcription factors NF-kappa B, Spt23p and Mga2p, which are generated from precursors by proteasomal processing. How distinct protein domains are spared from degradation remains a matter of debate. Here, we discuss several models and suggest a novel mechanism for proteasomal processing.

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AnimalsCysteine EndopeptidasesModels, BiologicalMultienzyme ComplexesNF-kappa BProteasome Endopeptidase ComplexProtein Structure, TertiaryTranscription FactorsUbiquitinJournal Article

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Michael Rape, Stefan Jentsch. 2002. Taking a bite: proteasomal protein processing.. https://doi.org/10.1038/ncb0502-e113

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