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PubMed · 11929243

Deoxyribozyme-based logic gates.

Milan N Stojanovic·Tiffany Elizabeth Mitchell·Darko Stefanovic
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Abstract

We report herein a set of deoxyribozyme-based logic gates capable of generating any Boolean function. We construct basic NOT and AND gates, followed by the more complex XOR gate. These gates were constructed through a modular design that combines molecular beacon stem-loops with hammerhead-type deoxyribozymes. Importantly, as the gates have oligonucleotides as both inputs and output, they open the possibility of communication between various computation elements in solution. The operation of these gates is conveniently connected to a fluorescent readout.

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Base SequenceBiosensing TechniquesDNA, CatalyticDrug DesignLogicMolecular Sequence DataNucleic Acid ConformationOligonucleotidesJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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Milan N Stojanovic, Tiffany Elizabeth Mitchell, Darko Stefanovic. 2002-04-10. Deoxyribozyme-based logic gates.. https://doi.org/10.1021/ja016756v

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