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Results for “Logic”

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At least 19 recordsLinked to original sources
PubMed1977

Computer test logics for automatic perimetry.

Using an automatic computerized perimeter developed by Heijl & Krakau (1975b) three different perimetric test logics, one simple (I) and two more complicated and time-consuming (II & III) were investigated in practical experiments on healthy normal test subjects and patients and in computer simulated tests. The patients either had a verified diagnosis of glaucoma or glaucoma was suspected. The best consistency in measured thresholds was obtained with test logic II, in which an averaging procedure is used. The variation of the results was larger in pathological than in normal visual fields. All test logics investigated readily detected the pathological field defects, but blind spots could easier pass unrecognized with the simplest logic than with the other two logics. The conclusion is drawn that a simple test logic can be used for perimetry in glaucoma suspects if no visual field defect has previously been documented. For the follow-up of pathological fields a fairly complicated test logic, e.g. using averaging, is preferable.

Adult↗
PubMed2025

Boolean matrix logic programming for active learning of gene functions in genome-scale metabolic network models.

Reasoning about hypotheses and updating knowledge through empirical observations are central to scientific discovery. In this work, we applied logic-based machine learning methods to drive biological discovery by guiding experimentation. Genome-scale metabolic network models (GEMs) - comprehensive representations of metabolic genes and reactions - are widely used to evaluate genetic engineering of biological systems. However, GEMs often fail to accurately predict the behaviour of genetically engineered cells, primarily due to incomplete annotations of gene interactions. The task of learning the intricate genetic interactions within GEMs presents computational and empirical challenges. To efficiently predict using GEM, we describe a novel approach called Boolean Matrix Logic Programming (BMLP) by leveraging Boolean matrices to evaluate large logic programs. We developed a new system, [Formula: see text], which guides cost-effective experimentation and uses interpretable logic programs to encode a state-of-the-art GEM of a model bacterial organism. Notably, [Formula: see text] successfully learned the interaction between a gene pair with fewer training examples than random experimentation, overcoming the increase in experimental design space. [Formula: see text] enables rapid optimisation of metabolic models to reliably engineer biological systems for producing useful compounds. It offers a realistic approach to creating a self-driving lab for biological discovery, which would then facilitate microbial engineering for practical applications.

Active learning↗
PubMed1975

Logical operations and role-taking abilities in two cultures: Norway and Hungary.

9 Piagetian measures of conservation, classification, and role taking, and a task designed to test verbal egocentrism were administered to children in 3 social settings in rural Hungary. The work is an extension of research carried out by Hollos and Cowan in Norway. In each setting 45 male and female children with equal numbers of 7-, 8-, and 9-year-olds were tested. Factor analysis yielded a logical-operations factor and a role-taking factor. Age and setting effects were significant for both factors. The socially isolated children performed less well on role-taking tasks but did significantly better on logical operations at all ages than village and town children. The results are almost identical with the findings of the Norwegian study, further supporting a threshold hypothesis regarding the amount of social interaction needed for the development of logical operations. Language stimulation and the effect of linguistic role marking in Hungarian do not seem to be significant factors, nor is schooling.

Child↗
PubMed1977

Logic as a tool for clinical training in social work.

The paper is an attempt to illustrate the usefulness of logic as a technique in the clinical training of mental health professionals. The specific concepts that are examined include the nature of deductive and inductive reasoning, hypothesis testing, necessary and sufficient conditions, "if-then" propositions, and the nature of clinical evidence. Knowledge and use of these concepts was tested in a tutorial program directed toward students who were beginning graduate studies in the field of social work. Some of the difficulties encountered by these students, especially in the clinical aspects of their training, were directly related to an inadequate understanding of these logical forms of reasoning. It is suggested that a portion of the clinical training in mental health fields be directed towards a deeper understanding and utilization of these basic concepts.

Curriculum↗
PubMed1976

On Ho's "modern logic and schizophrenic thinking".

The purpose of this note is to point out that conclusions drawn in the title paper about the role of logic in the schizophrenia thought process are not reliable, since they are based on patients medicated with antipsychotic drugs. The substance of this note is drawn from the title paper and related literature. The principal conclusion is that Dr. Ho's deductions about the role of logic in schizophrenia follow only if one confuses psychiatric diagnosis with psychotic behavior.

Antipsychotic Agents↗
PubMed1976

[Elementary logic and semantic fields in aphasia].

Modern linguistics, like genetic psychology, postulate a non-linguistic basis for the structurisation of the semantic fields. If such is the case, it should be possible to observe in aphasia, where semantic deficiency predominates, a related disturbance in the semantic fields and logic. Paraxodically, such disturbances have been observed both in Broca's aphasia and in the predominantly semantic aphasia of Wernicke. A qualitative analysis shows that quantitatively identical results in the semantic aphasias of Broca and Wernicke are the result of phenomenological convergence. The related disturbance in the semantic fields and logic appears characteristic of the semantic deficiency which, in aphasic semiology, is marked by the substitution of one word for another. These finding support the theory of the relative autonomy of phonemic and semantic disorders in Wernicke's aphasia. They confirm the linguistic and genetic theory that the structure of vocabulatory is based on extralinguistic factors. They do not however provide an explantation for semantic disorders in aphasia. Further research is required to discover on what functional system articulation of the symbolic function and general operative capacity is based.

Adolescent↗
PubMed1975

Use of logic-based flow patterns in the investigation and management of surgical disorders.

The principles used in the development of logic-based flow charts for use by computer have been applied to the decision-making processes encountered in surgical disorders. Such charts do not attempt to alter one's decisions, but rather present a more logical approach to a given problem, based on past experience. It has been shown that the use of flow charts may be of material benefit to the patient, as well as having other advantages.

Catheters, Indwelling↗
PubMed1978

The logical analysis of the electroenterogram.

Simple--and inexpensive--logic circuitry is described which will discriminate three types of spike activity in the canine electroenterogram. Used during high-speed replay of tape-recorded myoelectric activity, it provides a numerical analysis of the duration and spike content of the three types of activity, without the need for sophisticated (and costly) computer analysis. The ability of the analyzer to detect types of activity is illustrated by the analysis of the effects of a peptide hormone infusion on the canine electroenterogram. The device might also serve as the prototype for other applications in which simple digital logic could be used to detect different patterns in continous analog signals.

Animals↗
PubMed1977

General-purpose timer from transistor logic to auxiliary equipment.

This paper describes a low-cost circuit for the control and timing of auxiliary experimental equipment by a variety of signals from 5 V, integrated-circuit logic. The circuit is designed for variable timing and switching up to 240 AC V at 3 A, with two independent timing parameters, delay and duration, in response to positive-going or to negative-going logic signal transitions.

Electronics, Medical↗
PubMed2025

Characterizing the regulatory logic of transcriptional control at the DNA sequence level by ensembles of thermodynamic models.

MOTIVATION: Understanding how the genome encodes the regulatory logic of transcription is a main challenge of the post-genomic era, and can be overcome with the aid of customized computational tools. RESULTS: We report an automated framework for analyzing an ensemble of fits to data of a thermodynamics-based sequence-level model for transcriptional regulation. The fits are clustered accordingly with their intrinsic regulatory logic. A multiscale analysis enables visualization of quantitative features resulting from the deconvolution of the regulatory profile provided by multiple transcription factors interacting with the locus of a gene. Quantitative experimental data on reporters driven by the whole locus of the even-skipped gene in the blastoderm of Drosophila embryos was used for validating our approach. A few clusters of highly active DNA binding sites within the enhancers collectively modulate even-skipped gene transcription. Analysis of variable enhancers' length shows the importance of bound protein-protein interactions for transcriptional regulation. The interplay between activation and quenching enables function conservation of enhancers despite length variations. AVAILABILITY AND IMPLEMENTATION: The transcription factor level data used for performing the reported study is accessible in the input files in Zenodo and GitHub as well the full code. Additional data from formerly FlyEx database will be available under request.

Thermodynamics↗
PubMed1977

The logical levels of complementary, symmetrical, and parallel interaction classes in family dyads.

It was postulated that the parallel interaction class is a higher logical order than complementary and symmetrical interaction, which appear to be of the same logical type. Father-mother, father-child, and mother-child dyads of 48 families were categorized into complementary, symmetrical, and parallel classes using the Relationship Styles Inventory. Each of the dyads in these three categories was then randomly assigned to one of two experimental conditions in which they jointly resolved a moral dilemma. In one condition, the dyads were asked to follow complementary rules, while in the second condition they were instructed to follow symmetrical rules. Results indicated that parallel dyads adjusted to both the complementary and symmetrical conditions, whereas symmetrical and complementary dyads did not successfully accomodate rules outside their own class. The implications in terms of therapeutic intervention and further research are discussed.

Adolescent↗
PubMed1979

Untangling the logics of urban service bureaucracies: the strange case of the San Francisco Municipal Railway.

Marxist analysts have developed theoretical propositions concerning the conflicting functions of government in advanced capitalist countries, while public policy analysts have examined the logic of public resource allocation. Through an historical analysis of a typical urban bureaucracy, the San Francisco Municipal Railway, this paper describes how bureaucratic structure and functioning relate to broader conflicts over whom government actions should benefit. It concludes that the apparent shortcomings of the organization can be traced to, and were caused by, this conflict. The argument thus draws from each of these two quite different approaches to the question of what logic motivates the public sector.

California↗
PubMed1978

Intermingling and disordered logic as influences on schizophrenic 'thought disorders'.

A technique was devised to elicit bizarre or idiosyncratic responses from 30 young schizophrenics, who were then re-interviewed a week later to determine the reasons for each patient's idiosyncratic verbalizations. Taped interviews of the schizophrenics, scored along a series of rating scales, indicated: (1) An overt mechanism involved in bizarre schizophrenic language is a tendency to intermingle into their responses material from their current and past experiences. (2) Careful analysis suggests that the seemingly bizarre intermingled material of schizophrenics usually is close to the original "correct" topic. (3) The bizarre intermingled material is related to the patients' personal lives. (4) The intermingled material does not usually represent a failure to screen out or repress primitive drive dominated sexual or aggressive material. (5) Disordered logic was not a major factor in accounting for bizarre schizophrenic language.

Adult↗
PubMed1976

Medication, logic, and schizophernic thinking: a reply to Marini.

This article attempts to answer Marini's critique of my paper and to clarify the issue of medication in the study of the role of logic in the production of schizophrenic thought. It is argued that clinical observations do not lead one to believe that either the form or the content of schizophrenic thought disorder changes in any fundamental way as a result of medication. Consequently, the fact that most of the schizophrenic Ss were medicated at the time of the original research does not negate the conclusion that the thinking pathology found in schizophrenics cannot be accounted for by positing a basic defect in their deductive reasoning process.

Antipsychotic Agents↗
PubMedDate not supplied

Conceptualization: knowledge and logic guiding empirical research.

This article analyzes functions and processes of research conceptualization. The most prevailing limitation of nursing research, as represented in its published literature, concerns the relevant use of knowledge and logic for the formulation of that which is to be studied. To that end, the components of the conceptual phase of research, as they develop progressively from the initiating question through the stipulation of the specific purpose of a study, are discussed. For each component emphasis is given to the function served by past knowledge toward the generation of new knowledge.

Concept Formation↗
PubMed1975

Diurnal variation in logical reasoning.

Subjects performed two tests of logical reasoning at each of six different times of day. In terms of speed, preformance on both tests was found to improve markedly from 08.00 to 14.00 and then to fall off fairly rapidly. Accuracy was found to decrease fairly linearly over the day. The results are interpreted as indicating that the different functions relating performance efficiency to time of day found by previous workers are due to differences in task demands rather than to individual differences. It is suggested that the larger the short-term memory component of a task the earlier in the day performance peaks.

Achievement↗
PubMed1975

[Hypnosis: logic and cybernetics].

Fundamental notions concerning cybernetics, as derived from the systematic application of logic to questions of communication and control, are illustrated. Particular attention is given to the concepts of "system" "structure" and "dynamics" and it is shown that these concepts ensure that better and more exact understanding and forecasting of reactions in organised beings can be obtained. Turing to hypnosis, it is made clear that a trance is the execution of a momentarily proposed programme; it is not the result of a generalised mechanical action, but is preordained and geared to various situations. The difficulty that the hypnotised subject finds in aciting against his own interests, or against moral priniciples, can be seen, for example, as a consequence of pre-programming. Another result is given moment and a given type of person. Since cybernetis has proved useful in psychology, the hope is expressed that it can be included as a teaching subject for those who learn, practise and teach hypnotism.

Cybernetics↗