Increased interleukin 4 (IL-4) receptor expression and IL-4-induced decrease in IL-12 production by Langerhans cells infected with Leishmania major.

Heidrun Moll; Anabel Scharner; Eckhart Kämpgen

doi:10.1128/iai.70.3.1627-1630.2002

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Increased interleukin 4 (IL-4) receptor expression and IL-4-induced decrease in IL-12 production by Langerhans cells infected with Leishmania major.

Heidrun Moll·Anabel Scharner·Eckhart Kämpgen

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Abstract

Langerhans cells (LC) take up Leishmania major and are critical for the induction of the parasite-specific T-cell response. Their functional activities are regulated by cytokines. We analyzed whether infection of LC with L. major modulates the expression of their cytokine receptors. The expression of the interleukin 4 (IL-4) receptor was increased on infected LC from susceptible mice but not on those from resistant mice. Moreover, IL-4 treatment strongly decreased the lipopolysaccharide-induced IL-12 response of infected LC from susceptible mice. This modulation of IL-4 receptor expression and IL-12 production by infection of LC with Leishmania may contribute to the development of Th2 cells and to susceptibility to infection.

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Animals Interleukin-12 Interleukin-4 Langerhans Cells Leishmania major Mice Mice, Inbred BALB C Mice, Inbred C57BL Receptors, Interleukin-4 Journal Article Research Support, Non-U.S. Gov't

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Heidrun Moll, Anabel Scharner, Eckhart Kämpgen. 2002. Increased interleukin 4 (IL-4) receptor expression and IL-4-induced decrease in IL-12 production by Langerhans cells infected with Leishmania major.. https://doi.org/10.1128/iai.70.3.1627-1630.2002

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