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PubMed · 11636535

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I Kalaykov
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Abstract

Certain aspects are investigated in the development of Bulgarian natural science in connection with the 25th anniversary of the victory of the Socialist revolution in Bulgaria. An attempt is made to divide in periods the methodological re-organization of Bulgarian natural science. Some of the more significant achievements and weak points in dealing with the philosophical problems of Bulgarian natural science are analyzed; also natural history issues are outlined, the philosophical elucidation of which is forthcoming, closely related to the modern development of the science and the state of ideological struggle.

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BulgariaCommunismHistory, 20th CenturyNatural HistoryScienceSocialismEnglish AbstractHistorical ArticleJournal Article

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I Kalaykov. 1970. [Not Available].. https://pubmed.ncbi.nlm.nih.gov/11636535/

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IGF1, growth pathway polymorphisms and schizophrenia: a pooling study.

It has been hypothesized that insulin-like growth factors (IGFs) and components of the growth-hormone (GH)-IGF axis may underlie reported associations of poor fetal and childhood growth with schizophrenia. We have investigated the association of schizophrenia with 16 SNPs spanning the IGF1 gene with an inter-marker distance of approximately 2-3 kb. We also examined associations with four common functional polymorphisms of genes involved in aspects of the GH-IGF system--the IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), growth hormone (GH1), and IGF binding protein-3 (IGFBP3). The study was based on an analysis of pooled DNA samples from 648 UK and Irish cases of schizophrenia and 712 blood donor controls and of 297 Bulgarian parent offspring trios. In replicated pool analyses, none of the 16 SNPs in IGF1 nor the 4 key SNPs in the other growth pathway genes were associated with schizophrenia. SNP coverage of IGF1 was extensive, so our findings do not support a major role for IGF-I in the aetiology of schizophrenia.

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