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PubMed · 11484833

Hypertonic-hyperoncotic solutions decrease cardiac troponin I concentrations in peripheral blood in a porcine ischemia-reperfusion model.

T Bertsch·C Denz·C Janke·M Weiss·K Fassbender·T Luiz·K Ellinger·H Krieter
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Abstract

In this study we addressed the question of whether the measurement of cardiac Troponin I (cTnI) is able to reflect beneficial effects of hypertonic-hyperoncotic solutions after transient cardiac arrest. Ten pigs were anaesthetized and cardiac arrest was induced by electric fibrillation. After 5 minutes of global ischemia, cardiac arrest was reversed by electric defibrillation. Upon return of spontaneous circulation 5 animals received hypertonic-hyperoncotic solutions (10% Hydroxyethylstarch 200/0.5 and 7.2% NaCl). The other animals received equivalent volumes of physiological saline. We observed that cTnI serum levels of animals treated with hypertonic-hyperoncotic solutions were significantly lower than those treated with saline. We conclude that hypertonic-hyperoncotic solutions may have cardioprotective effects.

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AnimalsBiomarkersDisease Models, AnimalHemodilutionHemoglobinsHydroxyethyl Starch DerivativesHypertonic SolutionsMyocardiumReperfusion InjurySwineTroponin IJournal ArticleResearch Support, Non-U.S. Gov't

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T Bertsch, C Denz, C Janke, M Weiss, K Fassbender, T Luiz, K Ellinger, H Krieter. 2001. Hypertonic-hyperoncotic solutions decrease cardiac troponin I concentrations in peripheral blood in a porcine ischemia-reperfusion model.. https://doi.org/10.1078/0940-2993-00176

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