PubMed · 11372085
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B J Marshall, G Y Ho. 2001. Controls not matched.. https://doi.org/10.1136/adc.84.6.525j
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The recent article, "Comparison of Telephone Sampling and Area Sampling: Response Rates and Within-Household Coverage" (Am J Epidemiol 2001;153:1119-27), raised a number of issues related to two sampling methodologies that can be used for selecting population-based controls for case-control studies: random digit dialing (RDD) and area probability sampling. Some of these issues are discussed in this commentary in more detail to help in making sample design decisions, including the need to take the analysis plan into account when developing a sample design. Data from the paper are used to illustrate how the choice of sample design can affect analyses. Relative costs associated with the two methodologies as well as variance and bias concerns are also discussed in detail. Sample coverage issues, including those associated with list-assisted RDD, are considered, as are some advantages of the list-assisted approach. A discussion of the use of concurrent screening and sampling with an RDD approach as an alternative to periodically selecting fixed sample sizes is provided.
8-Hydroxyguanine is a mutagenic base lesion produced by reactive oxygen species. The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA. A population-based (245 cases and 222 controls) and family-based (159 hereditary prostate cancer families) association study was performed to test the hypothesis that sequence variants of hOGG1 increase susceptibility to prostate cancer. We found that the genotype frequency of two sequence variants (11657A/G and Ser326Cys) was significantly different between cases and controls. The association with 11657A/G is confirmed and strengthened by our family-based association study. These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1.
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