Memory T lymphocytes.

P G Ashton-Rickardta; J T Opferman

doi:10.1007/s000180050007

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Memory T lymphocytes.

P G Ashton-Rickardta·J T Opferman

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Abstract

Immunological memory protects organisms from recurrent challenge by pathogens. The persistence of a heightened reactive state initiated by antigenic challenge is mediated by long-lived memory lymphocytes. The survival of memory T cells is thought to require stimulation through the T cell receptor (TCR), sometimes by persistent antigen. However, memory T cells can survive in the absence of antigen, in which case TCR stimulation provided by cell surface self-peptide/ major histocompatibility complex (MHC) molecules and cytokines are required to sustain memory T cells. Recent work using mouse models has provided insights into the origin of memory T cells. Understanding the mechanisms that underlie the differentiation and persistence of memory T cells may improve the effectiveness of vaccines through the induction of T cell memory.

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Animals Cell Survival Immunologic Memory Mice Models, Biological Phenotype Receptors, Antigen, T-Cell T-Lymphocytes Time Factors Vaccines Journal Article Review

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P G Ashton-Rickardta, J T Opferman. 1999-10-01. Memory T lymphocytes.. https://doi.org/10.1007/s000180050007

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