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PubMed · 10950305

Life without myoglobin.

D J Garry·A Meeson·Z Yan·R S Williams
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Abstract

Hemoproteins are widely distributed among prokaryotes, unicellular eukaryotes, plants and animals [1]. Myoglobin, a cytoplasmic hemoprotein that is restricted to cardiomyocytes and oxidative skeletal myofibers in vertebrates, has been proposed to facilitate oxygen transport to the mitochondria [1-3]. This cytoplasmic hemoprotein was the first protein to be subjected to definitive structural analysis and has been a subject of long-standing and ongoing interest to biologists [1-3]. Recently, we utilized gene disruption technology to generate mice that are viable and fertile despite a complete absence of myoglobin [4]. This unexpected result led us to reexamine existing paradigms regarding the function of myoglobin in striated muscle.

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AnimalsBiological TransportGene Expression RegulationMiceMice, KnockoutMuscle, SkeletalMyocardiumMyoglobinOxygenJournal ArticleReview

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D J Garry, A Meeson, Z Yan, R S Williams. 2000. Life without myoglobin.. https://doi.org/10.1007/pl00000732

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