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PubMed · 10903565

A time-less function for mouse timeless.

A L Gotter·T Manganaro·D R Weaver·L F Kolakowski·B Possidente·S Sriram·D T MacLaughlin·S M Reppert
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Abstract

The timeless (tim) gene is essential for circadian clock function in Drosophila melanogaster. A putative mouse homolog, mTimeless (mTim), has been difficult to place in the circadian clock of mammals. Here we show that mTim is essential for embryonic development, but does not have substantiated circadian function.

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AnimalsCLOCK ProteinsCell Cycle ProteinsChimeraCircadian RhythmGenes, ReporterHeterozygoteHumansIntracellular Signaling Peptides and ProteinsLuciferasesMiceMice, Inbred StrainsMice, KnockoutMolecular Sequence DataMutagenesis, Site-DirectedPhylogenyRecombinant ProteinsSpodopteraSuprachiasmatic NucleusTrans-ActivatorsTranscription FactorsTranscription, GeneticTransfectionJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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A L Gotter, T Manganaro, D R Weaver, L F Kolakowski, B Possidente, S Sriram, D T MacLaughlin, S M Reppert. 2000. A time-less function for mouse timeless.. https://doi.org/10.1038/77653

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