Human thyroid-stimulating hormone: structure-function analysis.

M W Szkudlinski; M Grossmann; H Leitolf; B D Weintraub

doi:10.1006/meth.2000.0976

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Human thyroid-stimulating hormone: structure-function analysis.

M W Szkudlinski·M Grossmann·H Leitolf·B D Weintraub

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Abstract

This article provides the reader with an overview of methodological strategies to investigate structure-function relationships of human thyroid-stimulating hormone (hTSH). Various aspects of hTSH production, purification, and characterization described here in more detail are not only relevant to studies on other members of the glycoprotein hormone family, but also applicable to studies of other glycosylated proteins. Knowledge of structure-function relationships of specific hTSH domains is important for a better understanding of the molecular mechanisms of its action. New insights from such studies permit the design of glycoprotein hormone analogs with specific pharmacological properties and potential clinical applications.

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Animals Biological Assay Circular Dichroism Databases, Factual Humans Male Models, Biological Mutation Oligosaccharides Protein Engineering Protein Structure, Tertiary Rats Recombinant Proteins Structure-Activity Relationship Thyrotropin Time Factors Journal Article Research Support, Non-U.S. Gov't

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M W Szkudlinski, M Grossmann, H Leitolf, B D Weintraub. 2000. Human thyroid-stimulating hormone: structure-function analysis.. https://doi.org/10.1006/meth.2000.0976

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