Replication and recombination intersect.

K J Marians

doi:10.1016/s0959-437x(00)00059-9

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PubMed · 10753777

Replication and recombination intersect.

K J Marians

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Abstract

A bacterial housekeeping function, which requires both recombination and replication enzymes, has been identified that re-establishes inactivated replication forks under normal growth conditions. Some long-tract gene-conversion events initiated by double-strand breaks in yeast and mammalian cells can be attributed to recombination-directed DNA replication. Double-strand break repair in yeast has been shown to require both leading- and lagging-strand DNA synthesis. These observations suggest that the recombination and replication machinery cooperate to maintain genomic integrity.

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Animals DNA Replication DNA, Bacterial Humans Recombination, Genetic Journal Article Research Support, U.S. Gov't, P.H.S.Review

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K J Marians. 2000. Replication and recombination intersect.. https://doi.org/10.1016/s0959-437x(00)00059-9

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