Peptide hormone precursor processing: getting sorted?

L Canaff; H P Bennett; G N Hendy

doi:10.1016/s0303-7207(99)00129-x

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Peptide hormone precursor processing: getting sorted?

L Canaff·H P Bennett·G N Hendy

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Abstract

Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans.

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Animals Carboxypeptidase H Carboxypeptidases Endopeptidases Hormones Humans Mice Mice, Knockout Molecular Chaperones Mutation Nerve Tissue Proteins Neuroendocrine Secretory Protein 7B2 Peptides Pituitary Hormones Protein Precursors Protein Processing, Post-Translational Journal Article Review

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L Canaff, H P Bennett, G N Hendy. 1999-10-25. Peptide hormone precursor processing: getting sorted?. https://doi.org/10.1016/s0303-7207(99)00129-x

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