AKAPs: from structure to function.

M Colledge; J D Scott

doi:10.1016/s0962-8924(99)01558-5

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PubMed · 10354567

AKAPs: from structure to function.

M Colledge·J D Scott

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Abstract

Compartmentalization of signalling molecules through association with anchoring proteins ensures specificity in signal transduction by placing enzymes close to their appropriate effectors and substrates. For example, 'A-kinase anchoring proteins' (AKAPs) bind to the regulatory subunit of cAMP-dependent protein kinase (PKA) to direct the kinase to discrete intracellular locations. Recently, functional studies aimed at disrupting AKAP-PKA complexes have demonstrated a role for anchored PKA in various cellular processes, including gene transcription, hormone-mediated insulin secretion and ion-channel modulation. By binding to additional signalling molecules, AKAPs might function to coordinate multiple components of signal-transduction pathways.

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Carrier Proteins Cell Compartmentation Cyclic AMP Cyclic AMP-Dependent Protein Kinases Membrane Proteins Protein Binding Signal Transduction Journal Article Research Support, U.S. Gov't, P.H.S.Review

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M Colledge, J D Scott. 1999. AKAPs: from structure to function.. https://doi.org/10.1016/s0962-8924(99)01558-5

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