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The effects of an intravenous nicotine challenge on the ventilation and activity of rib cage muscles were studied in 33 pentobarbitone-chloralose anaesthetized cats. Bolus injection of nicotine (200 microg) into the right femoral vein evoked in 19 of the intact animals prompt, short-lived apnoea, or prolongation of the first expiration after the drug, the occurrence of which was significantly reduced by midcervical vagotomy (P < 0.001). In breaths that followed the apnoea, peak activity of the parasternal intercostal muscles increased from a baseline of 3.1 +/- 0.8 to 9.2 +/- 1.8 arbitrary units (P < 0.001). Nicotine produced a similar increase in peak phrenic ENG (7.0 +/- 0.5 to 14.5 +/- 1.2 arbitrary units; P < 0.001). Peak triangularis sterni muscle EMG was reduced from 8.9 +/- 1.2 to 6 +/- 1.7 arbitrary units (P < 0.05) and the onset of response was delayed to 30 s after the challenge. The changes of respiratory effectors induced by nicotine were independent of vagal integrity. The results show that post-nicotine apnoea is to large extent vagally dependent though the response of the respiratory muscles is mediated by non-vagal influences.

Anesthesia↗