Ca2+ and synaptic plasticity.

R Chittajallu; S Alford; G L Collingridge

doi:10.1016/s0143-4160(98)90061-6

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PubMed · 10091007

Ca2+ and synaptic plasticity.

R Chittajallu·S Alford·G L Collingridge

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Abstract

A major effort in neuroscience is directed towards understanding the roles of Ca2+ signalling in the induction of synaptic plasticity. Here, we summarize the evidence concerning Ca2+ signalling, paying particular attention to CA1 excitatory synapses, and its relationship to the induction of long-term potentiation and long-term depression. We discuss the ways in which synaptic activation can elevate Ca2+ postsynaptically and how dendritic spines may act as a Ca2+ compartment which can both isolate and integrate Ca2+ signals.

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Animals Calcium Hippocampus Long-Term Potentiation Neuronal Plasticity Journal Article Review

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R Chittajallu, S Alford, G L Collingridge. Ca2+ and synaptic plasticity.. https://doi.org/10.1016/s0143-4160(98)90061-6

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