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PubMed · 10066131

Cold exposure and immune function.

R J Shephard·P N Shek
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Abstract

The influence of cold exposure on immune function is reviewed. Data obtained mainly on small mammals suggest that the acute effect of severe chilling is a suppression of several cellular and humoral components of the immune response, including a decrease of lymphocyte proliferation, a down-regulation of the immune cascade, a reduction of natural killer (NK) cell count, cytolytic activity, activation of complement, and the induction of heat shock proteins. However, adaptation to a given cold stimulus appears to develop over the course of 2-3 weeks. Further work is needed to examine interactions between cold exposure and exercise, and to determine whether the disturbances of immune response are sufficient to impair immunosurveillance in human subjects.

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AnimalsCold TemperatureCytokinesEicosanoidsHormonesHumansImmunityInfectionsLymphocyte ActivationUrticariaJournal ArticleResearch Support, Non-U.S. Gov'tReview

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R J Shephard, P N Shek. 1998. Cold exposure and immune function.. https://doi.org/10.1139/cjpp-76-9-828

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