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Biomedical subjects

Z Wu

Publications and source records attributed to Z Wu.

At least 757 records · Page 42Linked to original sources
PubMed1991

[A study of textile noise influence on maternal function and embryo-growth].

Ninety hundred seventy-eight female textile workers exposed to noise (greater than or equal to 85 dB (A)) were recruited as the subjects of observation group, and 402 nonexposed female workers were chosen as the controls (less than 75 dB (A)). According to noise level, the observation group was subdivided into three groups: group 1, 100-104 dB (A), 416 workers; group 2, 95-99 dB, (A), 310 workers; group 3, 85-94 dB (A), 252 workers. Non-conditional logistic regression model was used to exclude the effect of mixed factors, such as age and working life. The result showed that noise-exposure could have some adverse effect on reproductive function of women and embryo growth. The workers exposed to noise had significantly increased incidence rates for irregular menstrual cycle, dysmenorrhea, lumbago, hypertension in pregnancy, threatened abortion, spontaneous abortion, premature labour, dystocia and low birth weight of newborns. When the noise intensity heightened, the sorts of abnormal function of reproduction increased and the risk of incidence raised too. These demonstrated a dose-response relationship between the noise intensity and incidence rate. The noise-working life had significant effects on the incidence of hypertension in pregnancy and prematurity. Although the age had some influence, it was not statistically significant. In terms of the maternal function and embryo growth, the factors in order of risk are: noise intensity greater than working life greater than age.

Abortion, Spontaneous↗
PubMed1991

[Choroidal malignant melanoma (clinical and pathologic studies of 42 cases)].

Clinical and pathologic studies of 42 cases of choroidal malignant melanoma are reported. We discussed: (1) The diagnosis of early stage cases and later cases with complication. (2) The prognosis is related to the size of tumor, the skill level of surgery, and whether tumor cell invades the superficial sclera of venous duct.

Adolescent↗
PubMed1990

Induction and purification of O6-methylguanine-DNA-methyltransferase from rat liver.

O6-Methylguanine-DNA-methyltransferase (OMMT) is a DNA repair protein that plays an important role in chemotherapy, mutagenesis and carcinogenesis. The sp. act. of OMMT in rat liver can be induced by approximately 12- to 20-fold by treatment of the rats with ionizing radiation. The effects of dose and time were investigated in this study. We have found that OMMT sp. act. can be increased, although to a lower extent, in kidney, spleen and brain in addition to liver. However, the sp. act. of OMMT in lung was reduced by irradiation. OMMT has been purified from the livers of irradiated rats by solubilization in high-salt-containing buffer, ammonium sulfate precipitation and a series of column chromatographic steps, including phenyl-Sepharose, heparin-agarose, double-stranded DNA-cellulose and FPLC. A 3000-fold enrichment of OMMT was achieved from the induced liver preparations. However, with regard to the sp. act. of this protein in normal rat liver, the fold purification was approximately 35,000. After methylation, OMMT during the course of its action exhibited a mol. wt of 28 kd under SDS-PAGE conditions.

Animals↗
PubMed1990

Pharmacokinetics and coronary thrombolytic properties of two human tissue-type plasminogen activator variants lacking the finger-like, growth factor-like, and first kringle domains (amino acids 6-173) in a canine model.

The pharmacokinetics and thrombolytic properties of two variants of recombinant human tissue-type plasminogen activator (rt-PA) were studied in dogs with a copper coil induced thrombosis of the left anterior descending coronary artery. The first variant, rt-PA-delta FEK1-Gln184, lacked amino acids 6 to 173 [comprising the fibronectin finger-like (F), the epidermal growth factor-like (E), and the first kringle (K1) domains] and had the glycosylated Asn184 mutagenized to Gln. The second variant, rt-PA-delta FEK1-Gln184, Val277, had in addition Lys277 mutagenized to Val. Injection of 0.25, 0.50, or 1.0 mg/kg of rt-PA in groups of three dogs caused reflow in six of nine dogs, within 18 +/- 15 min (mean +/- SD), but was associated with reocclusion within 2 h in all animals. Injection of 0.125, 0.25, or 0.50 mg/kg of rt-PA-delta FEK1-Gln184 caused reflow in all of nine dogs, within 17 +/- 23 min, with persistent patency in four animals (p = 0.02 vs. rt-PA). Bolus injection of 4:1 mixtures of rt-PA-delta FEK1-Gln184 and rt-PA in total amounts of 0.125, 0.25, or 0.50 mg/kg resulted in reflow in eight of nine dogs within 25 +/- 21 min with persistent patency in seven (p = 0.003 vs. rt-PA, p = 0.25 vs. rt-PA-delta FEK1-Gln184 alone). Injection of 0.25, 0.50, or 1.0 mg/kg of rt-PA-delta FEK1-Gln184, Val277 produced reperfusion in six of nine dogs, within 27 +/- 26 min, with persistent patency in three (p = 0.59 vs. rt-PA and p = 0.23 vs. rt-PA-delta FEK1-Gln184).(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acid Sequence↗
PubMed1990

Sequential assessment of pulmonary epithelial diethylene triamine penta-acetate clearance and intrapulmonary transferrin accumulation during Escherichia coli peritonitis.

The individual roles of pulmonary capillary endothelial and alveolar epithelial permeability in the pathogenesis of the adult respiratory distress syndrome (ARDS) are unclear. We developed a method for the sequential assessment of pulmonary macromolecule accumulation and small solute clearance in vivo using a gamma camera. We measured the exponential clearance coefficient of 111In-labeled diethylene triamine penta-acetate (111In-DTPA) to assess airway clearance of small solutes. We also calculated the exponential equilibration coefficient of 111In-labeled transferrin (111In-TF) to assess intrapulmonary accumulation of transferrin. We determined these parameters in guinea pigs with Escherichia coli peritonitis and compared them with a saline-treated control group, oleic-acid-treated groups, and a group treated with low molecular weight dextran Ringer solution. The pulmonary DTPA clearance and the intrapulmonary transferrin accumulation were significantly increased in the peritonitis group (29.4 +/- 8.2 x 10(-3) min-1, p less than 0.02, and 15.1 +/- 3.1 x 10(-3) min-1, p less than 0.02) when compared with the control group (3.1 +/- 0.8 x 10(-3) min-1 and 4.5 +/- 0.5 x 10(-3) min-1). These changes developed within 5.5 h of the initial insult. Neither increased extravascular lung water nor elevated pulmonary artery and left atrial pressures were detected in the peritonitis group. The low molecular weight dextran Ringer group did not show a significant increase in the pulmonary DTPA clearance and the intrapulmonary transferrin accumulation.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1990

[Diterpenoid constituents in bulbs of Fritillaria anhuiensis S.C. Chen et S.F. Yin].

The bulb of Fritillaria anhuiensis, a substitute for the traditional Chinese medicine Beimu, has been used as antibechic and expectorant. From the either soluble part of the bulb, four constituents were isolated and identified by spectral analysis (IR, MS, 1HNMR, 13CNMR) as beta-sitosterol, daucosterol, ent-kaur-15-en-17-ol and ent-kauran-16 beta, 17-diol.

Diterpenes↗
PubMed1990

[Effects of high carbohydrate and high fat diet on plasma apolipoproteins AI, AII, B100, CI, CII, CIII and E in normal and hypertriglyceridemic humans].

Effects of high carbohydrate (CHO) and high fat diet on plasma apolipoproteins (apo) AI, AII, B100, CI, CII, CIII and E were assessed in 10 healthy subjects and 10 patients with endogenous hypertriglyceridemia. High CHO diet consisted of 80% CHO, 5% fat and 15% protein of total calories, and high fat diet consisted of 40% CHO, 45% fat and 15% protein. After 5 days normal diet (60% of total calories from CHO, 25% from from fat and 15% from protein), the subjects studied received sequentially high CHO diet and normal diet for 5 days and high fat diet and normal diet for 5 days. Fasting blood samples were drawn on days 1, 3, and 5 of high CHO and high fat diet period, and 5 days after taking normal diet. Results showed that fasting plasma apo AI slightly decreased (P less than 0.01) on day 3 of the high CHO diet period and slightly increased (P less than 0.01) on day 3 of the high fat diet period, plasma apo AII increased after intake of high CHO diet, but no changes were observed after the subjects were placed on high fat diet. Fasting plasma apo B100 decreased (P less than 0.001) in hypertriglyceridemics on the 3rd day of the high CHO diet, but no differences were noted in normal subjects on the same diet. On the 3rd day of the high fat diet period, apo B100 increased (P less than 0.01) in normal subjects, but no changes were found in hypertriglyceridemics. Apo CII and CIII levels declined during the high CHO diet period but increased in normal subjects after intake of high fat died.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

[Relation of cytochemistry changes in the peripheral blood ANAE in chronic glomerulonephritis and differentiation-syndromes].

The ANAE reaction of the peripheral blood from 24 patients of chronic glomerulonephritis (grouped according to the identification of TCM) and 30 normal individuals were observed by cytochemistry and microspectrophotometry. It was found that the percentages of positive lymphocytes of the deficiency of Kidney-Yin was 47.8 +/- 7.6%, among which the percentages of lymphocytes of spot granular pattern and scattered granular pattern were 42.4 +/- 6.3% and 5.4 +/- 2.2% respectively, the ANAE relative quality of monocytes of the deficiency of Kidney-Yin was 51.26 +/- 2.59. They were 39.7 +/- 7.4%, 31.2 +/- 5.8%, 8.5 +/- 2.7% and 41.84 +/- 2.66 respectively in the deficiency of Kidney-Yang. The results of normal group were 65.5 +/- 6.8%, 53.6 +/- 6.7%, 11.9 +/- 3.4% and 54.78 +/- 3.34 in their given order. The differences in three groups each other were marked significantly. The authors have found the difference between the patients of chronic glomerulonephritis and the normal individuals was significant statistically.

Adult↗
PubMed1990

[Mosquito-net spraying with deltamethrin for malaria control].

Mosquito-nets were sprayed with 9.6mg deltamethrin per square meter for control of malaria vectors in Yibin County, Sichuan Province in 1986. In the study area, the relative population indices of Anopheles anthropophagus and An. sinensis in 35 mosquito-nets were 0.6 and 1.4 respectively; the man biting rates of these two vectors dropped by 97.8 and 90.8% respectively. The residual toxic effect of sprayed mosquito-nets, up to 104 days after spray, caused a mortality of 93.1-100% of An. anthropophagus and 87.1-100% of An. sinensis. The multiparous mosquito rate dropped by 48.4 and 51.3%. Indoor-intruding An. anthropophagus and An. sinensis were reduced by 76% and 78.3% respectively. The incidence of malaria decreased by 94.4%, the positive rate in school children declined by 77.5%. Both entomological and epidemiological indices indicated that mosquito-nets sprayed with deltamethrin could effectively control the malaria prevalence. This measure is economical and practical for control of malaria.

Animals↗
PubMed1990

Levels of sexual hormones in relation with syndrome-differentiation of TCM in patients of chronic renal failure.

Determinations of plasma levels of sexual hormones in 43 male patients of chronic renal failure showed that the content of testosterone (T) decreased markedly, while estradiol (E2) and E2/T ratio were obviously higher than in normal subjects, with no significant correlation between the levels of these sexual hormones and renal function. According to syndrome-differentiation of TCM, 17 of the 43 cases belonged to deficiency of Kidney-yang, and the other 26 cases deficiency of Kidney-yin. In the patients with deficiency of Kidney-yang, the E2 level was not increased, but the T content decreased to make the E2/T ratio apparently elevated; whereas in the patients with deficiency of Kidney-yin, both E2 and E2/T were elevated. The level of E2 in deficiency of Kidney-yin was markedly higher than that in deficiency of Kidney-yang. The results indicated that patients of chronic renal failure of the type of deficiency of Kidney-yang differed in syndrome as well as in levels of the sexual hormones from the type of deficiency of Kidney-yin; however, the sexual hormones were not correlated with the renal functions in the two types of patients.

Adult↗
PubMed1990

[Rupture of splanchnic artery aneurysms (a report of 19 cases)].

During the past 30 years, 19 patients were admitted in our hospital with acute rupture of splanchnic artery aneurysms. There were 12 hepatic artery, 5 gastroduodenal-pancreaticoduodenal and 2 superior mesenteric artery aneurysms. The aneurysms ruptured into the biliary tract in 13 patients, and 3 into the abdominal cavity, and 3 into the upper gastrointestinal tract. Twelve aneurysms resulted from choledochitis or pancreatitis, 5 from atherosclerosis and 2 from trauma. It is difficult to make a correct diagnosis preoperatively. The most valuable examination is selective angiography of the celiac and superior mesenteric arteries. Nine of our patients were correctly diagnosed preoperatively by arteriography. Thirteen patients were treated by surgery and 7 died. Prognosis depended on anatomic relations of the aneurysms and the primary underlying disease.

Adolescent↗