Seven patients with advanced forms of mediastino-pulmonary sarcoidosis (involvement of the pulmonary parenchyma, and restrictive respiratory syndrome), confirmed by histopathologic investigation, have been treated with a new SV-rifamycin derivative, 1246-EH, or "Reprimum" without any other association. Reprimun was given in daily doses of 10 mg/kg of body weight for a period of two weeks, then, for another 4-5 weeks, the drugs was given intermittently in doses of 15 mg/kg of body weight twice weekly. Between two cycles of therapy a period of 14 days was free of drug administration. In all patients the treatment with the new derivative was well tolerated. The treatment was not followed by adrenal deficiencies, neither was noted obesity, bone decalcification, gastric ulcers, etc., which are commonly associated with prolonged corticoid therapy. The treatment with "Reprimun" efficient for all patients. A clear clinical and X-ray improvement was noted after the first three months of treatment with the new drug. Respiratory function, as well as clinical and radiological signs improved, the serum immunologic parameters, and the biochemical ones were also significantly improved (Ig, C3 total serum proteins and gammaglobulins). All parameters which were tested were finally improved and became normal. In only two of the seven patients the radiological aspects of the lung suggested the presence of sequellae at the end of the treatment. In these two patients there was a persistant reduction in the respiratory volume, as well as a discret hypoxemia. However, both these patients had a more advanced form of the disease, with extensive pulmonary fibrosis, and in these cases prolonged corticoid therapy which had previously been applied had failed. Reprimun had an immunological-modulatory effect in all patients, resulting in normal levels of IgG, IgA, and C3 in the first three months of therapy. There was a direct correlation between the normalization of immunological indicators and the good evolution of the diseases, a fact which suggests once again the existence of some immune mechanisms involved in the maintenance of sarcoidosis.

Adult↗

PubMedDate not supplied

[Follow-up over a period of time of the pulmonary functional conditions in patients with COBP].

Explore the source record for details and available documents.

Adult↗

PubMedDate not supplied

Pulmonary mechanics in patients with asthma bronchiale in symptom-free interval.

Pulmonary and airway mechanics were assessed in 30 patients with asthma bronchiale during a symptom-free interval, and with normal spirometry. Static expiratory pressure-volume (PV) curves and maximum expiratory flow-volume curves were obtained, and maximum flow-static recoil (MFSR) curves were drawn-up. In 11 patients elastic pressures were significantly lower than normal at all lung volumes, but the slope of the PV curve was normal; the loss in lung elastic recoil was not associated with an increase in lung volume, suggesting that surface forces acting in the alveoli may be responsible for the elastic abnormality. In 5 patients static pressures were increased at all lung volumes, possibly due to the increase in elastic pull exerted by the thorax on the lungs. Obstruction of small airways was present in most cases: MEF50 was lower than predicted in 70% of them, and in 73.3% the upstream resistance was increased. In 17 subjects, the MFSR curves showed increased pressures at given maximal flows suggesting that the airways obstruction was generated by an intrinsic mechanism. In 4 cases, an extrinsic mechanism might be responsible since the elastic pressures at given maximal flows were lower than normal.

Adult↗