To enhance the drug uptake and release capacity of silicone rubber (SR), N-isopropylacrylamide (NIPA) hydrogel particles have been incorporated into a SR membrane. The NIPA particles were thoroughly blended with uncured SR with a certain ratio at room temperature. The mixture was then cast in a Petri dish to 1 mm thickness and cured 10 hours at 90 degrees C. The SR/NIPA composite gel can absorb water approximately equal to its dry weight. Brilliant blue, used as a mock drug, was loaded into the composite gel. Drug release increased exponentially to a final value that is temperature dependent: low at T> =34 degrees C, and high at T< 34 degrees C. This finding is because the hydrophobicity of NIPA changes with temperature. Pulsed release in response to temperature switching between 20 and 39 degrees C has been achieved. Drug uptake and release capability strongly depends upon the structure of the composite gel. The optimal range of NIPA composition is between 75 and 87% by volume. In the cited range, the NIPA particles form an interconnected network that provides a channel for diffusion of drug solution. The SR/NIPA composite gel has promising attributes as a wound dressing and other uses.

Acrylamides↗

PubMedDate not supplied

The change of C-fos expression in ovariectomized rats following electroacupuncture treatment--an immunohistochemistry study.

The roles of electroacupuncture (EA) in regulating the function of ovulation in rat have been investigated; however, the systematic study for the involvement of neural population of central nervous system (CNS) in acupuncturing the ovariectomized rat for promoting functional recovery has not been well understood. The present research was designed to examine, by C-fos immunocytochemistry, the distribution of Fos labelled neuron in CNS after acupuncturing the point of "Zhong-Ji (RN3)", "Guan-Yuan (RN4)", "San-Ying-Jiao (SP6)" and "Zi-Gong (EXCA1)" in ovariectomized rat. The area occupied by Fos protein labelled neuron, two hours after ovariotomy, was detected in medial preoptic nucleus (MPN), lateral preoptic nucleus (LPN), suprachiasmatic nucleus (SCN), paraventricular nucleus of the hypothalamus (PANH), medial amygdala nucleus (MAN), periventricular nucleus of the hypothalamus (PVNH), ventromedial nucleus of the hypothalamus (VNH), and arcuate nucleus (AR). The C-fos immunoreactive labelled neurons disappeared two weeks later following ovariotomy. The rat, recovering for two weeks after ovariotomy, received EA, and many specific Fos labelled cell were observed in LPN, PVNH, VNH, SCN and especially in AR, PANH and MPN, but not any labelled neuron could be found in MAN. No obvious C-fos expression was shown in these areas in the control group and EA group without ovariotomy. These results indicate that the above structures involved in regulating the function of hypothalamus-pituitary-ovarian axis and EA could modulate this function through effects on the above nuclei.

Animals↗