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Biomedical subjects

Z Dienstbier

Publications and source records attributed to Z Dienstbier.

At least 55 records · Page 3Linked to original sources
PubMed1986

Prognostic factors in Hodgkin's disease.

Between 1978-84 371 patients with HD were treated according to Protocol of LCG. 72.5% achieved complete, 10.8% partial remission and 16.7% were nonresponders. The evaluation of results was performed by PIL program from BMDP 81. The mean survival was 61 and disease-free survival (DFS) 60 months. The cumulative survival and DFS at 5 years were 65% and 68%, resp. Advanced HD, B symptoms, histopathology LD, male sex and age above 40 years influenced survival adversely. DFS decreased with CS III B, in males and age above 60 years significantly and in histopathology MC and LD with lack of significance. However, the size of mediastinal involvement was not a poor prognostic factor for survival, but influenced DFS. The prognostic value of major risk factors in HD was estimated by means of frequencies of their associations.

Adult↗
PubMed1985

Monoclonal antibodies against human urinary bladder carcinomas: selectivity and utilization for gamma scintigraphy.

Mouse monoclonal antibodies to human urinary bladder carcinoma cells have been examined by indirect membrane immunofluorescence using a panel of 27 human cell lines. Two of the monoclonal antibodies, 7E9 (IgG3) and S2C6 (IgGl), were found to distinguish between urinary bladder carcinoma cells and normal urothelium. The third monoclonal antibody, T24.06.5(IgGl), discriminated among cell lines of urothelial and non-urothelial origin but did not distinguish between urinary bladder carcinoma and normal urothelial cells. None of the of the antibodies was found to be strictly selective, and occasional cross-reactions with unrelated cell types were observed. The monoclonal antibody 7E9, showing the highest degree of selectivity, was further examined by an indirect immunoperoxidase technique on frozen tissue sections from 19 patients. The antibody reacted with all (7/7) bladder carcinomas examined and gave negative results with control normal bladder mucosa (0/8) and unrelated tumor tissue (0/4) sections. The 7E9 antibody was purified by protein A affinity chromatography, labeled with 131I and used for gamma-scintigraphy in nude mice xenografted with human urinary bladder carcinoma T24. The 7E9 antibody was capable of locating the T24 xenografts in nude mice; it localized preferentially in the T24 tissue compared to normal mouse tissues. The T24 xenografts could not be detected by gamma-scintigraphy with 131I-labeled monoclonal antibody against human mammary carcinoma cells and two other control antibodies. Likewise the 131I-labeled 7E9 antibody was not capable of locating human mammary carcinoma xenografts in nude mice.

Animals↗
PubMed1985

An international survey of medical school programmes on nuclear war.

Many medical organizations have acknowledged the responsibility of doctors to educate health professionals and the public about the medical, social and ecological consequences of nuclear war. Medical schools have begun the development of programmes on these topics. A total of 1130 medical schools in thirty-one countries were surveyed about their presentation of nuclear-war-related subject matter. Eighty-three (49%) of the 168 schools that responded indicated that they offered an activity on medical aspects of nuclear war. Thirty-two per cent of the programmes consisted of one or more hours in an existing required course. Twelve per cent offered an elective course solely concerned with nuclear war. Although only 15% of the schools responded many of the replies indicated interest in learning more about the programmes of other schools and inquired if curriculum or teaching materials were available. Through the survey it was learned that textbooks and other learning resources have been prepared. Survey information suggests that knowledge of nuclear weapons effects is associated with a reluctance to countenance nuclear war.

Curriculum↗
PubMed1985

Tumour localization of radiolabelled monoclonal antibody in mice bearing human urinary bladder (T24) carcinoma xenografts.

Selectivity of mouse monoclonal antibody 7E9 (IGG3) directed against human urinary bladder carcinoma cells has been examined by indirect membrane immunofluorescence, using a panel of 31 human cell lines. The 7E9 monoclonal antibody discriminated between urinary bladder carcinoma cells and normal urothelium or cells of non-urothelial origin, although occasional reactions with bladder carcinoma-unrelated cell types were observed. The 7E9 antibody was purified by protein A affinity chromatography, labeled with 131I and used for gamma scintigraphy in nude mice xenografted with human urinary bladder carcinoma T24. The 7E9 antibody was capable of locating the T24 xenografts in nude mice; it localized preferentially in the T24 tissue compared to normal mouse tissues. The T24 xenografts could not be detected by gamma scintigraphy with 131I-labelled monoclonal antibody against human mammary carcinoma cells and two other control antibodies. Likewise, the 131I-labelled 7E9 antibody was not capable of locating human mammary carcinoma xenografts in nude mice.

Animals↗
PubMed1984

Immunoscintigraphy and distribution study of experimental tumours using 131I-labelled anti-fibrinogen antibodies.

131I-labelled antibodies to the fragment E of human fibrin, anti-rat fibrinogen, non-immune rabbit IgG and 67Ga-citrate were used for scintigraphy and distribution studies in experimental tumours in rats. The best visualisation was achieved with 131I-labelled anti-rat fibrinogen antibodies at intervals longer than 48 h after administration. Tumour to tissue ratios found in distribution studies performed formed more than 48 h after administration were higher in most examined tissues when using 131I-labelled antibodies than those obtained with 67Ga-citrate.

Animals↗