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Biomedical subjects

Ying Zhao

Publications and source records attributed to Ying Zhao.

At least 55 records · Page 3Linked to original sources
PubMed2005

[The treatment of Semont maneuver for 40 patients with posterior semicircular canal benign paroxysmal positional vertigo].

OBJECTIVE: To evaluate the effectiveness of Semont maneuver for posterior semicircular canal benign paroxysmal positional vertigo (PC-BPPV). METHOD: Forty patients with PC-BPPV were treated with Semont maneuver from January to August in 2004. RESULT: After a single treatment session of Semont maneuver,the symptoms disappeared completely in 32 patients, the first success rate was 80%. Among 19 patients who had only 1 week duration of PC-BPPU, the symptoms disappeared in 16 patients after a single treatment. The symptoms disappeared in 3 patients after twice, 2 patients after 3 times and 1 patient after 4 times of Semont maneuver sessions, the total success rate was 95%. No effectiveness was found 2 patients; PC-BPPU recurred in 5 patients during follow-up and the recurrent rate was 12.5%. it was still effective for another Semont maneuver therapy session. CONCLUSION: The Semont maneuver therapy is safe and effective for PC-BPPV. Repeated Semont maneuver therapy is still effective for them.

Adult↗
PubMed2005

[Experimental study of using acellular dermal dermis instead of donor sclera in orbital implantation].

OBJECTIVE: To evaluate the histocompatibility of homologous acellular dermal matrix as a wrapping material for a hydroxyapatite orbital implant and compare the speed of fibrovascular ingrowth in hydroxyapatite orbital implant wrapped with homologous acellular dermal matrix and homologous sclera respectively. METHODS: Twenty four New Zealand rabbits were divided into two groups randomly. One group is implanted with hydroxyapatite orbital implant wrapped with homologous acellular dermal matrix behind the globe, the other group with homologous sclera. The observation included immunological reaction of the globe postoperation. Biopsies of implanted material were taken on weeks 1, 4, 8 and 12 postoperation for histopathological and electron microscope examination. RESULTS: Histological examination showed the homologous acellular dermal matrix has no immunological and inflammatory reaction after implanted in orbit. But the speed of fibrovascular ingrowth is a little slower than that of homologous sclera. CONCLUSIONS: The homologous acellular dermal matrix has the better histocompatibility as an encapsulating biomaterial, it can be a new material instead of homologous sclera.

Animals↗
PubMed2005

[Study on the structure of periodic and chaotic patterns of AMP-DC-Cu-gel systems].

This is an in vitro model to mimic the conditions present during gallstone formation. Adenosine mono-phosphate (AMP), an important bio-molecule, was chosen. Its effect on the formation of periodic/chaotic patterns in the deoxycholate-CuCl2-gel and deoxycholate-CuCl2-glucose-gel systems were studied. FTIR spectroscopy was used to identify the structure of the precipitates. The results indicate that the patterns formed in the systems with AMP are different. And FTIR spectra show that AMP may also be involved in the coordination sphere of Cu2+ ion. The results are more complicated in the deoxycholate-CuCl2 system containing glucose, suggesting that the nonlinear scientific concept should be considered in understanding gallstone formation.

Adenosine Monophosphate↗
PubMed2005

[Clinical study on the stability of palatal implant anchorage].

OBJECTIVE: To evaluate the clinical stability of the palatal implant anchorage system in orthodontic treatment. METHODS: Sixteen osseointegrated implants (5.0 mm in diameter, 6 mm length) were inserted in the median palatal suture area of 19 patients with malocclusion (average age: 18.22 +/- 7.10 years, from 11 years to 35 years 1 month) as anchorage of active orthodontic treatment with MBT appliance. The standard lateral cephalogram after implant placement and before implant removing was taken to compare the radiological parameters. RESULTS: The successful rate of palatal implant anchorage was 84.2%. The average duration of 16 palatal implant was 23.08 +/- 8.06 months (from 10 months to 36 months). There were no statistical differences in all parameters from the implant placement to the end of treatment. IL-X was from (62.88 +/- 5.85) mm to (62.45 +/- 6.70) mm, IL-Y was from (36.66 +/- 5.41) mm to (37.96 +/- 4.90) mm, IAP-PP was from (73.81 +/- 8.84) degrees to (74.72 +/- 9.22) degrees, IAP-Y was from (62.09 +/- 9.33) degrees to (63.85 +/- 10.96) degrees, U6-Y is from (20.80 +/- 5.87) mm to (21.49 +/- 6.00) mm. CONCLUSIONS: Stable palatal implant anchorage was maintained during active orthodontic treatment.

Adolescent↗
PubMed2005

[Preliminary report of fludarabine, mitoxantrone and dexamethasone in treating refractory or relapsed multiple myeloma].

BACKGROUND & OBJECTIVE: Multiple myeloma has low complete remission rate and high recurrence rate. Recurrence or relapse of the disease is almost inevitable for most of the patients after several cycles of combined chemotherapy. This study was designed to compare efficacy of fludarabine-based regimen (fludarabine, mitoxantrone and dexamethasone) with that of pirarubicin, vincristine and dexamethasone (VAD) on refractory or relapsed multiple myeloma, and analyze their toxicities. METHODS: Twenty-two patients who had received VAD regimen were taken as a historical control group. A total of 11 patients received FND regimen. The differences between FND group and VAD group were observed and compared. The following indexes were assessed before, during, and after treatment: the partial remission (PR) rate, total response rate, time to achieve PR, the number of patients and time of serum M-component drop to more than 50% of the pre-treatment value, the ratio of myeloma cells in bone marrow drop to less than 5% or more than 80% of pre-treatment level, and the hemoglobin level increase to more than 20 g/Lû the white blood cell and platelet count of the peripheral blood, serum calcium, creatinine, beta2-microglobin and glutamic-oxaloacetic transaminase (GPT) level, adverse events were also analyzed. RESULTS: The PR rate was significantly higher in FND group than in VAD group (45.5% vs. 22.7%, P<0.05). The median time to achieve PR was significantly longer in FND group than in VAD group (76 days vs. 68 days, P<0.05). The occurrence rates of M-component decrease and hemoglobin elevation were significantly higher in FND group than in VAD group [45.5% vs. 22.7%, and 54.5% vs. 18.2%, P<0.05]. There were no significant differences in serum calcium, creatinine and GPT level pre- and post-treatment between the 2 groups. The level of serum beta2-microglobin after treatment was significantly lower than that before treatment in FND group [(1 042.8+/-72.3) microg/L vs. (2 350.2+/-184.0) microg/L, P<0.05]. The nadir white blood cell count was significantly lower in FND group than in VAD group [(0.9+/-0.46)x10(9)/L vs. (2.09+/-0.6)x10(9)/L, P<0.05], and the occurrence rates of fever and cough was significantly higher in FND group than in VAD group (36.4% vs. 4.5%, 45.5% vs. 9.0%, P<0.05). CONCLUSIONS: Compare with VAD regimen, FND regimen may enhance the PR rate of refractory or relapsed multiple myeloma patients, but it takes longer time to achieve PR, and shows obvious bone marrow inhibition, with no significant renal or hepatic toxicity. FND regimen is effective and safe in treating refractory or relapsed multiple myeloma.

Adult↗
PubMed2005

[Expression and clinical significance of survivin in bone marrow cells of multiple myeloma patients].

BACKGROUND & OBJECTIVE: Survivin, a member of the inhibitors of apoptosis protein family (IAPs), is overexpressed in many cancers, but not in normal differentiated adult tissues. It is related to poor prognosis and resistance to chemotherapy and radiotherapy in many cancers. This study was designed to detect the expression of Survivin in bone marrow of healthy people, newly diagnosed and relapsed/refractory multiple myeloma (MM) patients, and MM cell line KM3, to explore its correlation to drug resistance and prognosis of MM patients. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) and Western blot were used to detect mRNA and protein expression of Survivin in bone marrow samples of 17 newly diagnosed MM patients, 12 relapsed /refractory MM patients, and 9 healthy people, and myeloma cell line KM3. RESULTS: KM3 cells expressed Survivin strongly. The positive rates and the expression levels of Survivin mRNA were significantly lower in healthy people than in newly diagnosed patients and relapsed/refractory patients (22.2 % vs. 70.5 % and 83.3 %, 0.06+/-0.04 vs. 0.31+/-0.14 and 0.69+/-0.24, P<0.01), and were significantly lower in newly diagnosed patients than in relapsed/refractory patients (P<0.05). Survivin protein were not detected in all of the healthy people; while the positive rates of Survivin were 41.4% in newly diagnosed patients and 58.3% in relapsed/refractory patients (P>0.05), and its expression levels was significantly higher in relapsed/refractory patients than in newly diagnosed patients (0.21+/-0.12 vs. 0.11+/-0.07, P<0.05). Among the 7 Survivin-positive newly diagnosed patients, 4 achieved partial remission (PR), 1 achieved MR, and 2 showed no change (NC); among the 10 Survivin-negative newly diagnosed patients, 2 achieved complete remission (CR), 4 achieved PR, 2 achieved MR, and 2 showed NC. The effective (CR+PR+MR) rate was slightly higher in Survivin-negative patients than in Survivin-positive patients (80.0% vs. 71.4%). CONCLUSION: High expression of Survivin may be relates to drug resistance in some patients. Since Survivin only expressed in bone marrow cells of multiple myeloma, but not in healthy people, it can be a new target to reverse drug resistance in myeloma cells.

Adult↗
PubMed2005

[Characterization of the orientation of polymer material by non-polarized raman laser light spectroscopy].

The non-polarized Raman laser light was used to investigate the anisotropic polymers including polypropylene fiber, nylon 6 flat fiber, and polyethylene pipe. The Raman spectra of the same samples with different location relative to the incident direction of laser beam show obvious differences. The present result extends the application of Raman spectroscopy to the characterization of oriented polymers samples.

Anisotropy↗
PubMed2005

[Study on the anticancer activities of the Clematis manshrica saponins in vivo].

OBJECTIVE: To study the anticancer activity of the Clematis manshrica saponins in vivo. METHOD: Anticancer activities were tested in mice with experimental tumor (S180, HepA and P388) in vivo. RESULT: The Clematis manshrica saponins showed a significant anticancer activities on Sarcoma-180, HepA and P388 implanted in mice. In S180 sarcoma, the average tumor inhibition rates were 42.78%, 52.06% and 58.25% (P < 0.05-0.01) respectively; The mean inhibition rates were 37.44%, 52.05% and 59.36% (P < 0.05-0.001) in Hep A tumor separately; while in P388 tumor, the mean inhibition rates were 34.50%, 46.78% and 54.39% (P < 0.05-0.01), respectively. CONCLUSION: The results indicate that Clematis manshrica has obvious antitumor effects against various transplanted tumor in mice.

Animals↗
PubMed2005

[Transpiration of Choerospondias axillaris in agro-forestrial system and its affecting factors].

Measurement of transpiration is essential to assess plant water use efficiency. Applying Grainer method, this paper measured the sap flow of Choerospondias axillaries in an agro-forestrial system, aimed to evaluate the effects of intercropping and pruning on the diurnal variation of transpiration, and to relate the transpiration rate with climatic factors. The results showed that the diurnal variation of Choerospondias arillaries transpiration rate appeared in parabola, low in the morning and evening, and high at noon. The transpiration rate was closely related to leaf stomatal conductivity and soil water potential, especially the water potential in 100 cm soil depth (R = 0.737). The transpiration rate of Choerospondias axillaries was increased by about 40% approximately 160% in agro-forestrial system through the changes in regional environment and in the deep soil water use by tree. Correlation analysis and multi-factor successive regression analysis indicated that the transpiration was controlled by ray radiation intensity, air temperature and ground temperature, followed by the difference between saturated and actual vapor pressure and the wind speed. A statistical model for calculating the sap flow rate by micrometeorological factors was also provided.

Crops, Agricultural↗
PubMed2005

[Novel infrared spectroscopy methods for clinical diagnosis of tumor].

In this paper, the authors have reviewed their investigation on the clinical detection of tumor tissues by infrared spectroscopy in recent ten years. Based on the comparison of different IR spectroscopic methods such as IR transmission spectroscopy, micro-IR spectroscopy etc, the authors found the good consistency of the results of ATR (attenuated total reglection) IR spectroscopic method with those of pathological biopsy. The authors have directly measured the IR spectra of frozen tissues stored in liquid nitrogen and freshly resected tissues, and have realized the measurement of tumor tissues in vito during the operation process using a specially designed IR spectrometer connected with a mid-IR fiberoptic with an ATR probe. The authors have investigated the malignant and normal tissues including parotid, esophagus, stomach, colon, liver, gallbladder, breast, thyroid etc. and compared with the pathological results. The accuracy of this novel IR detection method is more than 90%.

Humans↗
PubMed2005

[The studies on YCl3/PEU system by rheology analysis and FTIR].

FTIR spectroscopy and rheology analysis were applied to study the YCl3/PEU system. It is apparent that modification with lanthanide complexes such as yttrium leads to a slight increase in viscosity of the polyether urethane solution. The authors conclude that this may be due to the interaction between the lanthanide ions and the polar group in urethane.A new band appears at 1650 cm(-1) in the infrared spectra of the YCl3/PEU system, which corresponds to the new carbonyl structure formed through the coordination with yttrium cations. The dynamic rheological behaviors of the solutions demonstrate the interaction furthermore. A higher molecular weight formed with the higher concentration of the lanthanide ions in this DMF solution. And this could be an effective method to characterize the structure of the polymer solutions.

English Abstract↗
PubMed2005

[Synthesis, structure characterization and, fluorescence studies of the complexes of europium with phenylglyoxylic acid, 1,10-phenanthroline and triphenyl phosphine oxide].

Three novel europium complexes, Eu-L, EuL3phen and EuL2 (TPPO)2NO3, were synthesized (HL = phenylglyoxylic, phen= 1,10-phenanthroline, and TPPO = triphenyl phosphine oxide). The complexes were characterized by elemental analysis, conductivity, IR, and 1H NMR. The IR spectra indicated that all the complexes have a larger deltaupsilon(upsilon(as) (CO2-) - upsilon(s)(CO2-) than that of NaL, and carboxylate ions in the phenylglyoxyate coordinated as unidentate ligands. And alpha-aeto also coordinated with the europium ions. In 1H NMR, the signals of hydrogens in the phenylglyoxyate shifted toward upfield, and those in phen or TPPO slightly shifted. The excitation and emission spectra were recorded at room temperature, and the excitation spectra showed that the optimum excitation wavelengths were 374.0, 358.2 and 383.4 nm, Five emission bands of the complexes due to 5D(0)-7F(0), 5D(0)-7F(1), 5D(0)-7F(2), 5D(0)-7F(3) and 5D(0)-7F(4) transitions were observed in the region of 550-720 nm (Eu-L: 577.8, 590.2, 614.0, 648.4 and 695.4 nm; EuL3phen: 578.0, 588.4, 591.6, 611.2, 617.0, 649.4, 687.6 and 698.6 nm; EuL2 (TPPO)2NO3: 577.8, 590.4, 614.6, 649.2 and 697.6 nm). The emission intensities of europium ions were obviously sensitized by TPPO.

English Abstract↗
PubMed2004

Effects of treatment with and without adjuvant radiation therapy on recurrence of ocular and adnexal squamous cell carcinoma in horses: 157 cases (1985-2002).

OBJECTIVE: To determine the effects of treatment with and without adjuvant radiation therapy on recurrence of ocular and adnexal squamous cell carcinoma (SCC) at specific anatomic locations in horses. DESIGN: Retrospective study. ANIMALS: 91 horses. PROCEDURES: Medical records of horses with histologically confirmed ocular and adnexal SCC evaluated from 1985 to 2002 were reviewed. Sex, breed, age, type of treatment, location, and recurrence of SCC were recorded. Two treatment groups determined by recurrence of SCCs treated with and without adjuvant radiation therapy were established. RESULTS: The anatomic site with the highest recurrence rate was the limbus (junction of the cornea and sclera) or bulbar conjunctiva (477%), independent of treatment group. There was a significant difference in recurrence rates of ocular and adnexal SCCs between the 2 treatment groups, independent of anatomic location. Recurrence rates of SCCs treated with and without adjuvant radiation therapy were 11.9% and 44.1%, respectively. Recurrence rates for SCCs of the eyelid, limbus or bulbar conjunctiva, and cornea treated with adjuvant radiation therapy were significantly different from those for SCCs treated without adjuvant radiation therapy. The most frequently represented anatomic site for ocular and adnexal SCCs was the eyelid (28.7%). Coat color, breed, and the interaction of age and breed had a significant effect on tumor recurrence regardless of treatment type and anatomic location. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that ocular and adnexal SCCs treated with adjuvant radiation therapy had a significantly lower recurrence rate, compared with SCCs treated without adjuvant radiation therapy, independent of anatomic location.

Animals↗
PubMed2004

Petunia-shaped superstructures of CaCO3 aggregates modulated by modified chitosan.

This paper presents the crystallization behavior of calcium carbonate at the air/liquid interface of aqueous systems of carboxymethyl chitosan (CMCS) using the Kitano method. Although the synthesized CMCS (Mw approximately 100,000) with 1.57 degree of carboxymethyl substitution shows no surface activity, it controls the crystallization of calcium carbonate to form a petunia-shaped superstructure. The shuttlecock-like head of this superstructure strongly supports Colfen's opinion (Rudloff, J.; Colfen, H. Langmuir 2004, 20, 991-996) for the existence of a gas template of CO2 bubbles temporarily captured by polymer molecules, while formation of the stem of this superstructure is provisionally attributed to the presence of the strong electrostatic interactions between calcium ions and the carboxylate groups. The CaCO3 superstructure and its morphology depend not only on the polymer concentration but also on the combined number of calcium ions per CMCS molecule. These results imply that this simple and versatile method expands the morphological investigation of mineralization processes.

Air↗
PubMed2004

PPARgamma staining as a surrogate for PAX8/PPARgamma fusion oncogene expression in follicular neoplasms: clinicopathological correlation and histopathological diagnostic value.

The PAX8/PPARgamma (PPFP) fusion-oncogene is moderately specific for follicular thyroid carcinomas (FTC). It remains unknown whether this can be translated into improved diagnosis, classification, or outcome prediction. We studied a cohort of well-characterized follicular adenomas (FA), FTC, and Hurthle cell carcinomas (HCC) from patients with complete clinical follow-up, to determine whether PPARgamma immunohistochemistry (as a surrogate of PAX8/PPARgamma expression) helps to distinguish FA from FTC and to assess its diagnostic accuracy as an adjunct to frozen section. We also correlated PPARgamma staining with clinical outcomes to assess its role as a prognostic marker.PPARgamma staining was more common in FTC (31 of 54; 57%) than in HCC (one of 23; 4%) or FA (four of 31; 13%) (P < 0.000001). Adjunctive use of PPARgamma immunohistochemistry improved diagnostic sensitivity of intraoperative frozen section from 84% to 96% (P < 0.05) but reduced specificity from 100% to 90% (P < 0.05). PPARgamma staining was associated with favorable prognostic indicators (female gender, better tumor differentiation, and lesser risk of metastases).PPARgamma staining may be helpful in the differential diagnosis of FA, FTC, and HCC, particularly when diagnostic sensitivity of histomorphology is reduced (e.g. during intraoperative frozen section). PPARgamma staining also shows an association with favorable prognosis and may have a role in risk stratification.

Adenoma↗
PubMed2004

Prevalence of anthelmintic resistant cyathostomes on horse farms.

OBJECTIVE: To determine prevalence of anthelmintic resistance in cyathostome nematodes of horses in the southern United States. DESIGN: Cross-sectional study. ANIMALS: 786 horses on 44 farms and stables in Georgia, South Carolina, Florida, Kentucky, and Louisiana. PROCEDURE: Fecal egg count (FEC) reduction tests were performed on 44 large farms and stables. Horses on each farm were treated with an oral paste formulation of fenbendazole, oxibendazole, pyrantel pamoate, or ivermectin at recommended label dosages. A mixed linear model was fitted to the percentage reduction in FEC, accounting for differences among farms, states, ages, treatments, and treatment by state interactions. RESULTS: By use of a conservative measure of resistance (< 80% reduction), the percentage of farms with anthelmintic-resistant cyathostomes was 97.7%, 0%, 53.5%, and 40.5% for fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate, respectively. Mean percentage reductions in FEC for all farms were 24.8%, 99.9%, 73.8%, and 78.6% for fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate, respectively. Pairwise contrasts between states for each treatment revealed that in almost all instances, there were no significant differences in results between states. CONCLUSIONS AND CLINICAL RELEVANCE: The prevalence of resistance found in this study was higher than that reported previously, suggesting that anthelmintic resistance in equine cyathostomes is becoming a major problem. Furthermore, data from these 5 southern states, which are geographically and physiographically distinct, were remarkably similar. This suggests that drug resistance in cyathostomes is highly prevalent throughout the entire southern United States and probably nationwide.

Animals↗
PubMed2004

Nasal insulin delivery in the chitosan solution: in vitro and in vivo studies.

The effects of chitosan concentrations, osmolarity, medium and absorption enhancers in the chitosan solution on nasal insulin delivery were studied in vitro and in vivo. The penetration of insulin through the mucosa of rabbit nasal septum was investigated by measuring the transmucosal flux in vitro, while the nasal absorption of insulin in vivo was assessed by the efficiency in lowering the blood glucose levels in normal rats. It was demonstrated that increasing concentrations of chitosan up to 1.5% (w/v) caused an increase in the permeability of insulin across the nasal mucosa. Insulin given intranasally in hypo- or hyperosmotic formulation showed a higher hypoglycemic effect than insulin delivered in isoosmotic formulation. Insulin formulation in chitosan solution prepared with deionized water brought to a higher relative pharmacological bioavailability (Fr) value than that prepared with 50 mM pH 7.4 phosphate buffer. A formulation containing both 1% chitosan and 0.1% ethylenediaminetetraacetic acid (EDTA), 5% polysorbate 80 (Tween 80) or 1.2% beta-cyclodextrin (beta-CD) did not lead to a higher Fr than insulin formulated with 1% chitosan alone. The formulation containing both 5% hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and 1% chitosan was more effective at reducing blood glucose levels than the formulation containing 5% HP-beta-CD or 1% chitosan alone. The studies indicated that chitosan concentrations, osmolarity, medium and absorption enhancers in chitosan solution have significant effect on the insulin nasal delivery. The results of in vitro experiments were in good agreement with that of in vivo studies.

2-Hydroxypropyl-beta-cyclodextrin↗