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Biomedical subjects

Y Yamane

Publications and source records attributed to Y Yamane.

At least 289 records · Page 16Linked to original sources
PubMed1983

[Hypertrophic cardiomyopathy presenting ECG changes mimicking myocardial infarction during 18 years: report of a case].

This report describes a 54-year-old man with hypertrophic cardiomyopathy whose electrocardiogram had developed abnormal changes characterized by progressive ST-segment elevation with Q waves during eighteen years period. The ECG taken on the initial examination at his age of 36 showed a high voltage QRS complex with deep inverted T waves in V3-6. Twelve years later, these inverted T waves became shallow and ST-segment elevation was recognized. Since the age of 49, the ECG showed persistent ST-segment elevation and Q waves in V3-6 mimicking anterolateral myocardial infarction. At the age of 54, he suddenly died of ventricular tachycardia. At necropsy the heart showed the thickened ventricular septum and transmurally infarcted scar in the anteroseptal area near the apex with patent epicardial coronary arteries. Microscopic examination revealed myofibrillar disarray in the ventricular septum and significant intramural coronary artery narrowing in the left ventricular free wall and ventricular septum. The association of myocardial infarction in hypertrophic cardiomyopathy with the patent epicardial coronary artery has been reported by Maron et al, who stressed the role of the narrowing of intramural coronary arteries in such cases. In the present report, we discussed the pathogenesis of myocardial infarction in hypertrophic cardiomyopathy with a review of literature.

Cardiomyopathy, Hypertrophic↗
PubMed1981

Effect of copper administration on the incorporation of [3H]-thymidine into the liver DNA of rats stimulated by dimethylnitrosamine and diethylnitrosamine.

The incorporation of [3H]thymidine into liver DNA of rats increased 6--8 times 48 h after a single injection of dimethylnitrosamine (DMN, 30 mg/kg) and diethylnitrosamine (DEN, 100 mg/kg). To test the suppressive effect of copper, the incorporation of [3H]thymidine into liver DNA in the DMN groups or DEN groups pretreated with copper was measured 48 h after the administration of DMN or DEN. The incorporation of [3H]thymidine into liver DNA of rats stimulated by the injection of DMN was strikingly suppressed by the injection of cupric acetate (20 mg Cu/kg), but that of rats stimulated by the injection of DEN was not suppressed by the injection of copper. Some other metal salts, silver nitrate (20 mg Ag/kg), nickel acetate (20 mg Ni/kg) and basic lead acetate (20 mg Pb/kg) did not significantly suppress the incorporation of [3H]thymidine stimulated by DMN or DEN. The accumulation of copper was much higher in the liver of copper-administered rats than that of nickel or lead in the liver of nickel-administered rats or lead-administered rats. The accumulation of silver was comparatively high in the liver of silver-administered rats.

Animals↗
PubMed1981

[Clinical study on left atrial thrombi: comparative study between echocardiography and CT scan (author's transl)].

We studied left atrial thrombi (LAT) by both echocardiography and computed tomography (CT) and compared the features of the 2 methods. A total of 15 patients with mitral stenosis complicated by atrial fibrillation were selected as the subjects. LAT were noted on the M-mode echocardiograms in 2 patients including a questionably positive one, on the two-dimensional echocardiograms in 5, and on the CT scans in 6 of 15. The history of thromboembolism was rather frequent and was found in 7 of 15 patients. However, LAT was found in only 3 of these on the CT scans. A shaggy or fuzzy pattern on the M-mode echocardiogram cannot be regarded as representing thrombi, while a laminar pattern undoubtedly represented thrombi. Two-dimensional echocardiography has considerably contributed to the improved detection rate of LAT. For the characteristic properties of ultrasound beams, however, it was impossible to investigate the entire left atrium. The detection of the thrombi in the appendage was especially difficult. However, computed tomography, permitting transverse cross-sectional tomography, was capable of sectioning the heart even in the presence of air and bones. The measurement of CT values was suggestive of the properties of the substance or substances involved, and also allowed the presumption as to whether the thrombus has been fibrosed. Furthermore, it was possible to estimate more accurately as well as 3-dimensionally the location, shape and dimensions of the thrombi by the reconstruction of the heart according to the CT values. It was concluded that echocardiography and computed tomography are the mutual aid to further improvement in the detection rate of left atrial thrombi.

Aged↗
PubMed1981

Suppressive effect of aluminium chloride administration on mouse lung carcinogenesis by dimethylnitrosamine.

Dimethylnitrosamine was administered to mice by ip injection once a week for 3 weeks and a high incidence of lung tumor was found 6 approximately 8 months after the final injection. In experiment I, the incidence of mice with lung tumors was 74% and the average number of nodules per mouse was 15.6 within 6.0 months after the final injection of dimethylnitrosamine. In mice given aluminium pretreatment, these values decreased to 65% and 6.7 (P less than 0.05), respectively. In experiment II, the incidence of mice with lung tumors was 100% and the average number of nodules per mouse was 8.7 within 7.5 months after the final injection of dimethylnitrosamine. In mice given aluminium pretreatment, these values decreased to 79% and 4.6 (P less than 0.05), respectively.

Adenocarcinoma↗