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Biomedical subjects

Y Uzuka

Publications and source records attributed to Y Uzuka.

104 records · Page 6Linked to original sources
PubMed1975

[Laboratory studies on doxycycline intravenous (author's transl)].

The results of laboratory studies on doxycycline intravenous are summarized as follows: 1. The standard curves of doxycycline in five dilution systems were compared. Zones of growth inhibition were largest in the phosphate buffer solution at pH 7.2 and smallest in human serum. Lung system was close to the buffer system, liver system close to the serum system, and kidney system intermediate. 2. The doxycycline concentrations in blood of healthy male adults were compared by cross-over method. The concentration following intravenous injection of 200 mg, dissolved in 40 ml of 20% glucose and injected in 5 minutes, was high than that after oral administration of 200 mg immediately after the injection, but was same after 3 hours and thenafter. 3. No tendency of accumulation was observed in six volunteers injected intravenously with 100 approximately to 200 mg of doxycycline daily for three days. 4. In a patient with chronic broncho-bronchitis injected intravenously with 200 mg, the blood level reached a peak of 4.8 mcg/ml after 30 minutes, while the sputum level reached a peak of 1.8mcg/ml after 90 minutes. The sputum level was 30 to approximately 40% that of serum. 5. The urinary excretion of doxycycline was 94 mg/day (47.0%) after a single intravenous injection of 200 mg. and 53 mg/day (26.5%) after a single oral administration of 200 mg.

Administration, Oral↗
PubMedDate not supplied

Magnetic resonance imaging of the lateral ventricles in beagle-type dogs.

Magnetic resonance (MR) imaging was performed on 21 presumed normal Beagle-type dogs. The size and symmetry of their lateral ventricles were evaluated and dogs were categorized on the basis of the percentage of their ventricular height (Vh) to brain height (Bh) and the ratio of the largest to the smallest ventricular area (rVA). Eleven dogs had lateral ventricles classified as normal sized (0-14% Vh/Bh) while 10 of 21 dogs had moderate enlargement (15-25% Vh/Bh) of one or both lateral ventricles. None of the dogs had severe lateral ventricular enlargement. Degree of asymmetry was also arbitrarily categorized on basis of rVA as normal to minimal (rVA < 1.5), mild (1.5 < rVA < 2.0), or severe (2.0 < rVA). Of the dogs having normal-sized lateral ventricles, six of eleven had symmetric, three of eleven had mildly asymmetric and two of eleven had severely asymmetric lateral ventricles. Of the dogs having at least one moderately enlarged lateral ventricles, five of ten had symmetric lateral ventricles, and two of ten had mild asymmetry and three of ten had severe asymmetry. Gender and body weight had no statistical relationship to lateral ventricle symmetry. Clinically insignificant ventricular enlargement and asymmetry was common in this group of Beagle dogs.

Animals↗
PubMedDate not supplied

Developmental change of lateral ventricular volume and ratio in Beagle-type dogs up to 7 months of age.

Eighteen healthy Beagle-type dogs were studied using magnetic resonance (MR) imaging from a few days after birth up to 7 months of age. We evaluated the onset of lateral ventricular expansion, the developmental change of lateral ventricular volume and the ratio of the largest to the smallest lateral ventricular volume. The onset of lateral ventricular expansion was defined as the day that the expansion by cerebrospinal fluid (CSF) was first visible in unilateral or bilateral lateral ventricles on the transverse images at the level of the intraventricular foramen. It was found that the expansion of lateral ventricles were first detectable at 3-4 weeks. Lateral ventricular volume ratio varied most from the onset of lateral ventricular expansion to 75 days of age and stabilized after that, although absolute brain and lateral ventricular volumes continued to increase.

Animals↗
PubMedDate not supplied

Surgical and radiotherapy treatment of a spinal cord ependymoma in a dog.

A 4-year-old Beagle dog was presented for investigation of a left pelvic limb gait abnormality. Neurolocalisation indicated a lumbar (L2 to L5) spinal cord lesion. On magnetic resonance imaging (MRI), an intramedullary mass was demonstrated at L3. The mass was partially removed under general anaesthesia and a diagnosis of ependymoma was made on histological examination. The dog was treated with postoperative orthovoltage x-ray radiation (total dose; 44 Gy given in 11 fractions over a 4 week period) combined with low dose carboplatin (25 mg/m2). The dog was alive 16 months after surgery without further neurological deficits. No further tumour growth was detected on subsequent MRI evaluations.

Animals↗
PubMedDate not supplied

Brainstem auditory evoked responses elicited by tone-burst stimuli in clinically normal dogs.

Brainstem auditory evoked responses (BAERs) to click and tone-burst stimuli (0.5, 1, 2, 4, and 8 kHz) were recorded from 32 ears in 16 adult Beagles. BAERs were used to establish a normative database and describe response thresholds and latencies (wave I-IV) for the different stimuli. The frequencies of sound used were 8, 4, 2, 1, and 0.5 kHz. Sound stimuli were delivered by a closed headphone and masking stimuli were not applied. The BAER waveforms obtained were similar to those reported previously, except for a frequency-following response evoked by 1-kHz tone-bursts. The threshold was lowest when clicks and 4-kHz tone-bursts were used. Significant differences were observed between the mean values of the peak latencies for clicks and 4- and 8-kHz tone-bursts. The tone-burst stimulation used in our experiment was shown to be an appropriate method for detecting the BAERs. Thus, for investigating the frequency-specificity of the auditory sense, BAER data obtained using tone-burst sound in dogs may be meaningful.

Acoustic Stimulation↗
PubMedDate not supplied

Comparison of nonmetal and metal hydrophilic photosensitizer, ATX-S10 (Na) and ATN-2, binding with human serum proteins using spectrophotometry.

Intermolecular interactions of human serum proteins with a hydrophilic nonmetalloporphyrin, 13,17-bis(1-carboxypropionyl)carbomoylethyl-8-ethenyl-2-hydroxy-3-hydroxyiminoethylidene-2,7,12,18-tetramethylporphyrin sodium salt (ATX-S10 (Na)), or a hydrophilic gallium-metalloporphyrin, diethylenetriamine pentaacetic acid ester of 2-[1-(2-hydroxy-ethoxy)ethyl]-4-vinyl-deuteroporphyrin (IX) Ga complex (ATN-2), were investigated using spectrophotometry. ATX-S10 (Na) caused a bathochromic shift with albumin, high-density lipoprotein and low-density lipoprotein, but little or no shift was observed with hemopexin, transferrin and immunoglobulin G. In contrast, ATN-2 displayed a bathochromic shift only with hemopexin. These results suggest that the association energy of ATX-S10 (Na) with albumin might be slightly greater than that with lipoproteins and that of ATN-2 with hemopexin might be greater than that with other serum proteins.

Blood Proteins↗